As stated in the 2015 report, this project was scheduled for completion by December, 2015 and we met that planned completion date. During this reporting period, we completed development of a manganese-depleted growth medium and a detailed metabolomic analysis of Deinococcus radiodurans with relatively high and low resistance of gamma-irradiation. These were obtained by harvesting the bacteria at different phases of the growth curve. The analysis did not elucidate a metabolic basis for resistance.

Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2016
Total Cost
Indirect Cost
Name
U.S. National Heart Lung and Blood Inst
Department
Type
DUNS #
City
State
Country
Zip Code
Berlett, Barbara S; Levine, Rodney L (2014) Designing antioxidant peptides. Redox Rep 19:80-6
Daly, Michael J; Gaidamakova, Elena K; Matrosova, Vera Y et al. (2010) Small-molecule antioxidant proteome-shields in Deinococcus radiodurans. PLoS One 5:e12570