Resveratrol is a polyphenol found in plants and plant-based foods. Resveratrol protects against obesity and obesity-related diseases such as type 2 diabetes. The mechanism by which resveratrol confers these benefits is not known. We discovered that the metabolic benefits of resveratrol are mediated by inhibiting phosphodiesterase 4 in skeletal muscle. Resveratrol has also been reported to activate Sirt1. In mammals, the Sirtuins are composed of seven Sir2 orthologues (Sirt1-7) with a conserved deacetylase core that utilizes NAD+ as a cofactor. Sirtuins play an important role in energy metabolism and regulating Sirtuin activity may be useful for controlling fat accumulation. We found that resveratrol increases Sirt1 activity by increasing NAD+ in an AMPK-dependent manner.

Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2012
Total Cost
$1,108,695
Indirect Cost
Name
National Heart, Lung, and Blood Institute
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DUNS #
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