The initial phase of this study began in 2008 with the comparison of an electronic national prescription database and the medication history obtained by the Emergency Department (ED) nurse. The goal was to assess the degree to which data from a national prescription electronic database added to the routine medication history and the percent of ED patients who had such data. We showed that the prescription database, (which could be accessed securely from any hospital or clinic), increased the completeness of the patients' medication history by 28%. However, only two-thirds of the patients' prescription information could be found in the database. These results were published in a clinical journal in emergency medicine. Since then we obtained access to other sources of de-identified prescription and patient outcome information from: 1) Symphony Health Rx, a commercially available de-identified database with medication and encounter (with diagnoses) data. Symphony provided a one year sample containing more than 53 million prescription dispensings for 5.5 million people, with associated encounter information, from the Washington DC metropolitan area; b) from MIMIC II a large de-identified database of Intensive care data which we have also used to assess the independent risk of obesity on 30-day mortality after an ICU admission; and c) most recently we obtained access to the Centers for Medicare and Medicaid Services (CMS) Enclave with access to 6 years of prescription and 12 years of immunization, and 12 years of outcome data. With the additional databases we are obtaining experience with the use of big data to answer useful epidemiologic and clinical questions. Ongoing studies include: epidemiology of drug-drug interactions and the difference in the alerts generated by leading drug-drug interaction knowledgebases, incidence of prescriptions of potentially teratogenic drugs to pregnant women, and the association between influenza /pneumonia events and the timing of influenza vaccines, and association between Simvastatin use and Dementia/Alzheimer.

Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2015
Total Cost
Indirect Cost
Name
National Library of Medicine
Department
Type
DUNS #
City
State
Country
Zip Code
Drawz, Paul E; Archdeacon, Patrick; McDonald, Clement J et al. (2015) CKD as a Model for Improving Chronic Disease Care through Electronic Health Records. Clin J Am Soc Nephrol 10:1488-99
Demner-Fushman, Dina; Kohli, Marc D; Rosenman, Marc B et al. (2015) Preparing a collection of radiology examinations for distribution and retrieval. J Am Med Inform Assoc :
Ayvaz, Serkan; Horn, John; Hassanzadeh, Oktie et al. (2015) Toward a complete dataset of drug-drug interaction information from publicly available sources. J Biomed Inform 55:206-17
Abhyankar, Swapna; Demner-Fushman, Dina; Callaghan, Fiona M et al. (2014) Combining structured and unstructured data to identify a cohort of ICU patients who received dialysis. J Am Med Inform Assoc 21:801-7
Pan, Xuequn; Cimino, James J (2014) Locating relevant patient information in electronic health record data using representations of clinical concepts and database structures. AMIA Annu Symp Proc 2014:969-75
Winnenburg, Rainer; Bodenreider, Olivier (2014) A framework for assessing the consistency of drug classes across sources. J Biomed Semantics 5:30
Bodenreider, Olivier; Rodriguez, Laritza M (2014) Analyzing U.S. prescription lists with RxNorm and the ATC/DDD Index. AMIA Annu Symp Proc 2014:297-306
Fung, Kin Wah; Kayaalp, Mehmet; Callaghan, Fiona et al. (2013) Comparison of electronic pharmacy prescription records with manually collected medication histories in an emergency department. Ann Emerg Med 62:205-11
Fung, Kin Wah; McDonald, Clement; Srinivasan, Suresh (2010) The UMLS-CORE project: a study of the problem list terminologies used in large healthcare institutions. J Am Med Inform Assoc 17:675-80
Demner-Fushman, Dina; Chapman, Wendy W; McDonald, Clement J (2009) What can natural language processing do for clinical decision support? J Biomed Inform 42:760-72

Showing the most recent 10 out of 16 publications