Abstract

Four studies are actively recruiting to address the goal of the fatigue program. One study 09-NR-0088, """"""""Molecular-Genetic Correlates of Fatigue in Cancer Patients Receiving Localized External Beam Radiation Therapy"""""""" follows the fatigue symptoms of men with prostate cancer undergoing localized radiation therapy. Another study 09-NR-0131, """"""""Fatigue in Healthy Individuals"""""""" explores fatigue in healthy volunteers. The study 10-NR-0128, """"""""Relationship between Mitochondrial Dysfunction and Fatigue in Cancer Patients Following External Beam Radiation Therapy"""""""" specifically explores changes in the expression of mitochondrial genes that are associated with fatigue symptoms of prostate cancer patients receiving localized radiation therapy. A collaborative study with Georgetown University, Department of Rheumatology in Washington DC (OHSR Exempt #4966), explores the association between cytokine profile and gene expression findings with pain and fatigue symptoms of fibromyalgia patients before and after an exercise intervention. All these studies have collected a total of 137 PAX mRNA tubes for gene expression analysis, 313.5 mL of serum and 623.25 mL of plasma samples to run enzyme-linked immunosorbent assay for protein analyses for a total of 94 patients (21 prostate cancer patients, 69 healthy volunteers, 4 fibromyalgia patients).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIANR000019-01
Application #
8149621
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2010
Total Cost
$100,185
Indirect Cost

  Institution

Name
National Institute of Nursing Research
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Wolff, Brian S; Renner, Michael A; Springer, Danielle A et al. (2017) A Mouse Model of Fatigue Induced by Peripheral Irradiation. J Vis Exp :
Dougherty, John P; Wolff, Brian S; Cullen, Mary J et al. (2017) Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue. Pharmacol Res 124:1-8
Ortiz, Robin; Ballard, Elizabeth D; Machado-Vieira, Rodrigo et al. (2016) Quantifying the influence of child abuse history on the cardinal symptoms of fibromyalgia. Clin Exp Rheumatol 34:S59-66
Renner, Michael; Feng, Rebekah; Springer, Danielle et al. (2016) A murine model of peripheral irradiation-induced fatigue. Behav Brain Res 307:218-26
Cashion, Ann K; Gill, Jessica; Hawes, Rebecca et al. (2016) National Institutes of Health Symptom Science Model sheds light on patient symptoms. Nurs Outlook 64:499-506
Lukkahatai, Nada; Walitt, Brian; Espina, Alexandra et al. (2016) Understanding the Association of Fatigue With Other Symptoms of Fibromyalgia: Development of a Cluster Model. Arthritis Care Res (Hoboken) 68:99-107
Saligan, Leorey N; Luckenbaugh, David A; Slonena, Elizabeth E et al. (2016) An assessment of the anti-fatigue effects of ketamine from a double-blind, placebo-controlled, crossover study in bipolar disorder. J Affect Disord 194:115-9
Lukkahatai, Nada; Walitt, Brian; Espina, Alexandra et al. (2015) Comparing Genomic Profiles of Women With and Without Fibromyalgia. Biol Res Nurs 17:373-83
Saligan, Leorey N (2014) The relationship between physical activity, functional performance and fatigue in sarcoidosis. J Clin Nurs 23:2376-8
Lukkahatai, Nada; Majors, Benjamin; Reddy, Swarnalatha et al. (2013) Gene expression profiles of fatigued fibromyalgia patients with different categories of pain and catastrophizing: a preliminary report. Nurs Outlook 61:216-224.e2

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