During this period, the NCGC has fostered and maintained over 180 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to over 100 high-throughput screens and nearly 60 medicinal chemistry campaigns, providing our collaborators and the general research community a wealth of publications and promising small molecule leads. In addition, the NCGC has undertaken a number of informatic challenges to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.
| Agoulnik, Alexander I; Agoulnik, Irina U; Hu, Xin et al. (2017) Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1. Br J Pharmacol 174:977-989 |
| Kaftanovskaya, Elena M; Soula, Mariluz; Myhr, Courtney et al. (2017) Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290. J Endocr Soc 1:712-725 |
| Kocan, Martina; Sarwar, Mohsin; Ang, Sheng Y et al. (2017) ML290 is a biased allosteric agonist at the relaxin receptor RXFP1. Sci Rep 7:2968 |
| Hu, Xin; Myhr, Courtney; Huang, Zaohua et al. (2016) Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists. Biochemistry 55:1772-83 |
