Abstract

The collaborative team aims to identify relevant biomarkers and previously unrecognized therapeutic strategies for HD by integrating diverse experimental and computational strategies. During this period, the collaborative team screened compounds for protective activity in cells harboring expanded polyglutamine Htt. A focus was placed on testing compounds with reported targets and mechanism(s) of action. Using a quantitative systems pharmacology approach, the collaborative team aims to uncover cellular pathways that are critical for cell survival in Huntingtons disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIATR000315-03
Application #
10011415
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
National Center for Advancing Translational Sciences
Department
Type
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