Production of seasonal, pandemic and universal flu candidate plasmid DNA vaccines for use in human clinical trials. It is expected that these vaccines will be tested for safety and efficacy in Phase I trials in humans alone or as part of prime boost regimens. If found to be safe, these vaccines may proceed to testing in advanced clinical development programs. Several different serotypes of influenza vaccines are being manufactured, filled and released in compliance with current Good Manufacturing Practices (cGMP) that will be tested in preclinical (animal) challenge-efficacy studies.
| Liu, Jonathan; Mani, Sachin; Schwartz, Richard et al. (2010) Cloning and assessment of tumorigenicity and oncogenicity of a Madin-Darby canine kidney (MDCK) cell line for influenza vaccine production. Vaccine 28:1285-93 |
| Liu, Jonathan; Shi, Xiao; Schwartz, Richard et al. (2009) Use of MDCK cells for production of live attenuated influenza vaccine. Vaccine 27:6460-3 |
| Minor, Philip D; Engelhardt, Othmar G; Wood, John M et al. (2009) Current challenges in implementing cell-derived influenza vaccines: implications for production and regulation, July 2007, NIBSC, Potters Bar, UK. Vaccine 27:2907-13 |
