This project should be particularly informative in the area of regulation of transcript expression. The arrays have been done with Paul Metzer (Genomic Branch, CCR). Funding has been provided by David Goldstein (Office Of The Director, NCI). In addition to characterizing the methylation status of CpG islands for individual genes, it will provide indices of hypomethylation status, a common occurrence in cancer. More broadly, it will allow comparisons to any of our phenotypic, molecular, or pharmacological patterns. Data will be provided to the user in toto, in a queryable format (by gene or location), or as a gene centric """"""""Cell line signature"""""""" providing a synopsis of the methylation status of a genes CpG island on our CellMiner web-based application. This project is on going and not yet published or available as a public tool. Quality control has determined the work to be technically of good quality, and scientific analysis, tool development, and manuscript preparation are in progress.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICBC011499-02
Application #
8938486
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code