The CCR Collaborative Bioinformatics Resource (CCBR) is an organizational umbrella which provides a mechanism for CCR researchers to obtain many different types of bioinformatics assistance to further their research goals. This entity pulls together many different bioinformatics expertise within NCI, with strengths in a broad range of bioinformatics topics. The CCBR currently is providing support to over 60 Principal Investigators within CCR and are working on 112 projects related to several different general areas, including: 1) Data Mining: Analyzing public microarray data for Merkel cell carcinoma 2) Basic/Bench Research: Study of alternative splicing function of Rbfox1 in knock out and transgenic mice and Disruption of Pol II Elongation with O-GlcNAcylation Inhibitors 3)Translational Research: Genomic characterization of mouse model for GBM and Gene expression analysis of Kras-induced lung cancer mouse model 4) Clinical Research: Germline Exome-Seq analysis of Familial Non-Medullary Thyroid Cancer and Exome-Seq analysis of adrenocortical cancer germ line and tumor DNA
| Dine, Jennifer L; O'Sullivan, Ciara C; Voeller, Donna et al. (2016) The TRAIL receptor agonist drozitumab targets basal B triple-negative breast cancer cells that express vimentin and Axl. Breast Cancer Res Treat 155:235-51 |
| Kennedy, Mark W; Chalamalasetty, Ravindra B; Thomas, Sara et al. (2016) Sp5 and Sp8 recruit ?-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A 113:3545-50 |
| Rothermel, Luke D; Sabesan, Arvind C; Stephens, Daniel J et al. (2016) Identification of an Immunogenic Subset of Metastatic Uveal Melanoma. Clin Cancer Res 22:2237-49 |
| Peretti, Alberto; FitzGerald, Peter C; Bliskovsky, Valery et al. (2015) Genome Sequence of a Fish-Associated Polyomavirus, Black Sea Bass (Centropristis striata) Polyomavirus 1. Genome Announc 3: |
| Peretti, Alberto; FitzGerald, Peter C; Bliskovsky, Valery et al. (2015) Hamburger polyomaviruses. J Gen Virol 96:833-9 |
| Imashimizu, Masahiko; Takahashi, Hiroki; Oshima, Taku et al. (2015) Visualizing translocation dynamics and nascent transcript errors in paused RNA polymerases in vivo. Genome Biol 16:98 |
| Dummer, Patrick D; Limou, Sophie; Rosenberg, Avi Z et al. (2015) APOL1 Kidney Disease Risk Variants: An Evolving Landscape. Semin Nephrol 35:222-36 |
| Castro, Nadia P; Fedorova-Abrams, Natalie D; Merchant, Anand S et al. (2015) Cripto-1 as a novel therapeutic target for triple negative breast cancer. Oncotarget 6:11910-29 |
| Limou, Sophie; Dummer, Patrick D; Nelson, George W et al. (2015) APOL1 toxin, innate immunity, and kidney injury. Kidney Int 88:28-34 |
| Johnson, Randall C; Nelson, George W; Zagury, Jean-Francois et al. (2015) ALDsuite: Dense marker MALD using principal components of ancestral linkage disequilibrium. BMC Genet 16:23 |
Showing the most recent 10 out of 29 publications
