Imaging Probe Development Center

Griffiths, Gary Leonard

Abstract

The IPDC was one of three components of the molecular imaging aspect of the NIH Roadmap initiative, with the other two being high specificity/high sensitivity probes, and the set-up of an imaging probe database (MICAD). The IPDC produces known and new imaging probes for the NIH research community. The new IPDC laboratories began full operations early in calendar year 2007. The IPDC is now part of the NIH Intramural Program. For a complete listing of our projects, please refer to our website: https://intramural.nhlbi.nih.gov/OFFICES/IPDC/Pages/IPDCProjectList.aspx

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Scientific Cores Intramural Research (ZIC)
• Project #: 1ZICHL005090-06
• Application #: 8344979
• Support Year: 6
• Fiscal Year: 2011
• Total Cost: $2,998,254

Institution

• Name: National Heart, Lung, and Blood Institute

Publications

Kuszpit, Kyle; Hollidge, Bradley S; Zeng, Xiankun et al. (2018) [18F]DPA-714 PET Imaging Reveals Global Neuroinflammation in Zika Virus-Infected Mice. Mol Imaging Biol 20:275-283

Basuli, Falguni; Zhang, Xiang; Brugarolas, Pedro et al. (2018) An efficient new method for the synthesis of 3-[18 F]fluoro-4-aminopyridine via Yamada-Curtius rearrangement. J Labelled Comp Radiopharm 61:112-117

Brown, Zachary J; Fu, Qiong; Ma, Chi et al. (2018) Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development. Cell Death Dis 9:620

Basuli, Falguni; Zhang, Xiang; Jagoda, Elaine M et al. (2018) Rapid synthesis of maleimide functionalized fluorine-18 labeled prosthetic group using ""radio-fluorination on the Sep-Pak"" method. J Labelled Comp Radiopharm 61:599-605

Zhang, Xiang; Dunlow, Ryan; Blackman, Burchelle N et al. (2018) Optimization of 18 F-syntheses using 19 F-reagents at tracer-level concentrations and liquid chromatography/tandem mass spectrometry analysis: Improved synthesis of [18 F]MDL100907. J Labelled Comp Radiopharm 61:427-437

Basuli, Falguni; Zhang, Xiang; Williams, Mark R et al. (2018) One-pot synthesis and biodistribution of fluorine-18 labeled serum albumin for vascular imaging. Nucl Med Biol 62-63:63-70

Brugarolas, Pedro; Sánchez-Rodríguez, Jorge E; Tsai, Hsiu-Ming et al. (2018) Development of a PET radioligand for potassium channels to image CNS demyelination. Sci Rep 8:607

Opina, Ana Christina L; Strickland, Madeleine; Lee, Yong-Sok et al. (2016) Analysis of the isomer ratios of polymethylated-DOTA complexes and the implications on protein structural studies. Dalton Trans 45:4673-87

Zhang, Xiang; Basuli, Falguni; Shi, Zhen-Dan et al. (2016) Automated synthesis of [(18)F](2S,4R)-4-fluoroglutamine on a GE TRACERlab™ FX-N Pro module. Appl Radiat Isot 112:110-4

Strickland, Madeleine; Schwieters, Charles D; Göbl, Christoph et al. (2016) Characterizing the magnetic susceptibility tensor of lanthanide-containing polymethylated-DOTA complexes. J Biomol NMR 66:125-139