Abstract

In FY18, the Integrated Research Facility in the Division of Clinical Research has continued to provide research facilitation through core capabilities that include imaging, outbreak response in West Africa, clinical pathology, anatomic pathology, electron microscopy, confocal microscopy, immunology, and cell culture. Support was provided primarily to a large number of academic and industrial collaborators as well as to the Emerging Viral Pathogens section in the Division of Intramural Research (DIR) to facilitate discovery of medical countermeasures and improve diagnostics for emerging infectious diseases and biodefense pathogens. This facilitation was concentrated primarily on Ebola, Marburg, Nipah, and Lassa viruses and MERS CoV.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Clinical Support Services Intramural Research (ZID)
Project #
1ZIDAI009006-10
Application #
9796020
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Tamhankar, Manasi; Gerhardt, Dawn M; Bennett, Richard S et al. (2018) Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells. Virol J 15:135
DeWald, Lisa Evans; Dyall, Julie; Sword, Jennifer M et al. (2018) The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease. J Infect Dis :
Ward-Kavanagh, Lindsay K; Kokolus, Kathleen M; Cooper, Timothy K et al. (2018) Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors. Cancer Immunol Immunother 67:639-652
Cong, Yu; Hart, Brit J; Gross, Robin et al. (2018) MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells. PLoS One 13:e0194868
Pleet, Michelle L; Erickson, James; DeMarino, Catherine et al. (2018) Ebola Virus VP40 Modulates Cell Cycle and Biogenesis of Extracellular Vesicles. J Infect Dis :
Postnikova, Elena; Cong, Yu; DeWald, Lisa Evans et al. (2018) Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs. PLoS One 13:e0194880
Dyall, Julie; Johnson, Joshua C; Hart, Brit J et al. (2018) In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus. J Infect Dis :
Dyall, Julie; Nelson, Elizabeth A; DeWald, Lisa Evans et al. (2018) Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures. J Infect Dis :
Bramble, Matthew S; Hoff, Nicole; Gilchuk, Pavlo et al. (2018) Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors. J Infect Dis 218:1929-1936
Luke, Thomas; Bennett, Richard S; Gerhardt, Dawn M et al. (2018) Fully Human Immunoglobulin G From Transchromosomic Bovines Treats Nonhuman Primates Infected With Ebola Virus Makona Isolate. J Infect Dis :

Showing the most recent 10 out of 85 publications