Abstract

In FY18, the Integrated Research Facility in the Division of Clinical Research has continued to provide research facilitation through core capabilities that include imaging, outbreak response in West Africa, clinical pathology, anatomic pathology, electron microscopy, confocal microscopy, immunology, and cell culture. Support was provided primarily to a large number of academic and industrial collaborators as well as to the Emerging Viral Pathogens section in the Division of Intramural Research (DIR) to facilitate discovery of medical countermeasures and improve diagnostics for emerging infectious diseases and biodefense pathogens. This facilitation was concentrated primarily on Ebola, Marburg, Nipah, and Lassa viruses and MERS CoV.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Clinical Support Services Intramural Research (ZID)
Project #
1ZIDAI009006-10
Application #
9796020
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Ward-Kavanagh, Lindsay K; Kokolus, Kathleen M; Cooper, Timothy K et al. (2018) Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors. Cancer Immunol Immunother 67:639-652
Cong, Yu; Hart, Brit J; Gross, Robin et al. (2018) MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells. PLoS One 13:e0194868
Pleet, Michelle L; Erickson, James; DeMarino, Catherine et al. (2018) Ebola Virus VP40 Modulates Cell Cycle and Biogenesis of Extracellular Vesicles. J Infect Dis :
Postnikova, Elena; Cong, Yu; DeWald, Lisa Evans et al. (2018) Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs. PLoS One 13:e0194880
Dyall, Julie; Johnson, Joshua C; Hart, Brit J et al. (2018) In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus. J Infect Dis :
Dyall, Julie; Nelson, Elizabeth A; DeWald, Lisa Evans et al. (2018) Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures. J Infect Dis :
Bramble, Matthew S; Hoff, Nicole; Gilchuk, Pavlo et al. (2018) Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors. J Infect Dis 218:1929-1936
Luke, Thomas; Bennett, Richard S; Gerhardt, Dawn M et al. (2018) Fully Human Immunoglobulin G From Transchromosomic Bovines Treats Nonhuman Primates Infected With Ebola Virus Makona Isolate. J Infect Dis :
Davey Jr, Richard T; Dodd, Lori; Proschan, Michael et al. (2018) The Past Need Not Be Prologue: Recommendations for Testing and Positioning the Most-Promising Medical Countermeasures for the Next Outbreak of Ebola Virus Infection. J Infect Dis :
Iwasaki, Masaharu; Minder, Petra; Caì, Yíngyún et al. (2018) Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses. PLoS Pathog 14:e1006892

Showing the most recent 10 out of 85 publications