The Synthetic Organic Program will support the research of Dr. Peter A. Jacobi of the Department of Chemistry at Wesleyan University by means of an Accomplishment Based Renewal award. He will continue to develop methodology that leads to the preparation of ring-containing organic molecules. The specific process, known as bis-heteroannulation, affords fused-ring furans, prepared with complete regiochemical control. The key element in Dr. Jacobi's approach involves the intramolecular Diels-Alder reaction between an oxazole and an acetylene. In addition to the bis-heteroannulation work, tandem sigmatropic rearrangements will be used for the tranformation of acetylenic alcohols or enones into methylenecyclopentanones or phenols. Syntheses of a number of naturally occuring phenols and sesquiterpenes will illustrate the usefulness of the methodology.

Agency
National Science Foundation (NSF)
Institute
Division of Chemistry (CHE)
Application #
9001485
Program Officer
George M. Rubottom
Project Start
Project End
Budget Start
1990-04-01
Budget End
1993-09-30
Support Year
Fiscal Year
1990
Total Cost
$233,000
Indirect Cost
Name
Wesleyan University
Department
Type
DUNS #
City
Middletown
State
CT
Country
United States
Zip Code
06459