The overall objective is to develop Eldecalcitol (ED-71) for colorectal cancer prevention in a preclinical model. Specifically, the Contractor shall obtain required quantities of ED-71, establish the optimal dose and/or non-calcemic dose, perform in depth assessment of ED-7-mediated colon cancer prevention in APC-min mice, in addition to, identifying ED-71 specific molecular target(s) in preventing tumor frequency, incidence, multiplicity, etc. in APC-min mice.

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
261201200015I-0-26100005-1
Application #
8739520
Study Section
Project Start
2013-09-18
Project End
2014-09-17
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$303,650
Indirect Cost
Name
Research Institute of Fox Chase Cancer Center
Department
Type
DUNS #
064367329
City
Philadelphia
State
PA
Country
United States
Zip Code
19111