The overall goal of the Massachusetts General Hospital Proteomics Center is to establish the platform necessary for the discovery and validation of novel pathways and biomarkers triggered by myocardial ischemia. The Center proposes to build on their initial observations and working hypothesis that (1) an unbiased proteomics discovery platform will yield novel biomarkers and insights into pathways activated upon myocardial injury;(2) synergy exists between discovery efforts for clinical biomarkers and mechanistic models that will help identify the most robust pathways for further evaluation and (3) simultaneous assessment of multiple biomarkers examining different pathophysiological axes will provide complementary information to improve diagnosis and clarify prognosis, guide therapy, and provide targets for therapeutic modulation.

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
268201000033C-7-0-1
Application #
8727396
Study Section
Project Start
2010-08-15
Project End
2015-08-14
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$1,920,531
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199