Longevity combined with good health and functioning at the end of life is the goal of most individuals. Finding ways of promoting this condition is an important goal of the National Institute on Aging (NIA). Although research has been done on the correlates of long life and functional decline, we still know relatively little about why certain individuals live in excellent health into their 80's while others fail much sooner. In other words, how factors related to physiology and pathology affect longevity and healthy aging is not clear. It may be hypothesized that in older persons who escape diseases and disability, homeostatic mechanisms (integrity of anti-oxidant mechanisms, low level of oxidative damage to macromolecules, low inflammation, unimpaired autonomic reflexes, normal hormone levels etc.) should be relatively intact, with little accumulated damage. Understanding these mechanisms may open new opportunities of disability prevention.

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
271201000017C-8-0-1
Application #
8659291
Study Section
Project Start
2010-05-01
Project End
2015-04-30
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$650,176
Indirect Cost
Name
Westat, Inc.
Department
Type
DUNS #
049508120
City
Rockville
State
MD
Country
United States
Zip Code
20850