The removal of certain internal radioactive contaminants can be accomplished by administering chelating agents that can preferentially complex with radionuclides in the body and increase their rate of clearance, thereby decreasing radiation exposure. Pentetate (diethylenetriaminepentaacetate) calcium trisodium (Ca-DTPA) and pentetate (diethylenetriaminepentaacetate) zinc trisodium (Zn-DTPA) have been shown to be effective in treating internal contamination with radionuclides such as plutonium, americium, or curium. However, because DTPA must be given intravenously or by nebulizer, it is not useful in a mass casualty situation. This Contract advances the development of an oral form of DTPA that is more suitable for a mass casualty situation.

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
272201000030C-4-0-1
Application #
8752280
Study Section
Project Start
2010-09-30
Project End
2014-03-31
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$75,000
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599