The Laboratories for Reproductive Biology (LRB), www.med.unc.edu/lrb/faculty.htm, proposes to renew a multidisciplinary program for international research and training in reproductive biology leading to contraceptive development. In the new program we will build on successful collaborative relationships with the Universidade Federal de Sao Paulo?Escola Paulista de Medicina,Brazil, and the Shanghai Institute for Biological Sciences, China. These institutions have the potential to become leaders in reproductive biology within their respective countries. It is our goal to help them develop this potential and become stronger research and training programs that can effectively promote population research. Training/research expertise is provided infiveinterrelated areas: i) reproductive steroid hormone regulation of gene expression;2) molecular mechanisms regulating spermatogenesis;3) regulation of sperm maturation;4) fertilization and embryo implantation;5) innate immune systems ofthe male and female reproductive tracts. The U.S.training faculty consists of twelve members of the LRBat the University of North Carolina at Chapel Hill, one at Greenville Hospital System in Greenville, South Carolina,one adjunct member at North Carolina State University in Raleigh, and two adjunct members at the National Institute of Environmental Health Sciences in Research Triangle Park, NC. International collaborators in reproductive biology consist of four faculty members at the Universidade Federal de Sao Paulo?Escola Paulista de Medicine, Brazil, and fiveat the Shanghai Institute for Biological Sciences, China. Program emphasis is on further development of research collaborations with faculty in the foreign institutions and will include joint training ofpre-doctoral students leading to the Ph.D. degree at the foreign institution and training of postdoctoral scientists, followed by continued collaborative research upon return to the foreign site. Interactive research and training will be enhanced by regular exchange visits between U.S. and foreign faculty for seminars, workshops, in-depth discussions and planning of research and preparation of manuscripts. The program will produce investigators much needed to further our understanding ofmolecular mechanisms regulating reproductive functions and thereby provide the basis for developing better methods for fertility regulation and improvement of reproductive health. Ultimately the goal of our research is to help solve the major global problem of overpopulation and its multiple adverse effects on the health and well- being of humans.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW000627-15
Application #
7799851
Study Section
Special Emphasis Panel (ZRG1-BDA-A (90))
Program Officer
Liu, Xingzhu
Project Start
1995-09-30
Project End
2012-03-31
Budget Start
2010-04-01
Budget End
2012-03-31
Support Year
15
Fiscal Year
2010
Total Cost
$189,602
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Pediatrics
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Li, Xiangqi; Zhan, Xiaoni; Liu, Shigui et al. (2012) Cloning and primary characterizations of rLcn9, a new member of epididymal lipocalins in rat. Acta Biochim Biophys Sin (Shanghai) 44:876-85
Liu, Qiang; Su, Shifeng; Blackwelder, Amanda J et al. (2011) Gain in transcriptional activity by primate-specific coevolution of melanoma antigen-A11 and its interaction site in androgen receptor. J Biol Chem 286:29951-63
Hu, Shuanggang; Yao, Guangxin; Guan, Xiaojun et al. (2010) Research resource: Genome-wide mapping of in vivo androgen receptor binding sites in mouse epididymis. Mol Endocrinol 24:2392-405
O'Rand, M G; Widgren, E E; Wang, Zengjun et al. (2007) Eppin: an epididymal protease inhibitor and a target for male contraception. Soc Reprod Fertil Suppl 63:445-53
Wang, Zengjun; Widgren, E E; Richardson, R T et al. (2007) Eppin: a molecular strategy for male contraception. Soc Reprod Fertil Suppl 65:535-42
Yenugu, Suresh; Chintalgattu, Vishnu; Wingard, Christopher J et al. (2006) Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus). Reprod Biol Endocrinol 4:7
Radhakrishnan, Y; Hamil, K G; Yenugu, S et al. (2005) Identification, characterization, and evolution of a primate beta-defensin gene cluster. Genes Immun 6:203-10
Wang, Zengjun; Widgren, E E; Sivashanmugam, P et al. (2005) Association of eppin with semenogelin on human spermatozoa. Biol Reprod 72:1064-70
Jeyaraj, D Antony; Grossman, Gail; Petrusz, Peter (2005) Altered bioavailability of testosterone in androgen-binding protein-transgenic mice. Steroids 70:704-14
Petrusz, Peter; Jeyaraj, Durairaj A; Grossman, Gail (2005) Microarray analysis of androgen-regulated gene expression in testis: the use of the androgen-binding protein (ABP)-transgenic mouse as a model. Reprod Biol Endocrinol 3:70

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