The goal of this new application for the Global Infectious Disease Research Training Program is to enhance infectious disease research capacity in Peru, continuing to focus on research topics and experimental/ analytical approaches of highest priority as delineated by the faculty of Universidad Peruana Cayetano Heredia, Lima, Peru. Diseases of focus include major endemic and life-threatening diseases which may be ongoing problems or emerging or re-emerging: these include malaria, leishmaniasis, leptospirosis and Chagas Disease. New approaches in this competing renewal application include development of expertise and formal curriculum in experimental laboratory animal sciences, the role of climate change in infectious disease transmission (in collaboration with the Scripps Institution of Oceanography), and the development of state-of-the-art international video-teleconferencing between U.S. partners and Peru (Peruvian Amazon, Lima). The emphasis will on carrying out as much training of Peruvians in venues in Peru as possible, both at Lima and Iquitos. Short- and long-term training will be available in the U.S. for selected trainees whose subject areas require advanced training not available in Peru. The focus in the next training period will be on advanced degrees primarily obtained through UPCH, drawing upon sandwich programs with U.S. partners as articulated by Peruvian faculty priorities. Trainees will participate in competitive peer- reviewed, funded research projects, either short- or long-term. A graded series of experiences will allow a selection committee comprised of UPCH faculty to select the most highly qualified and motivated for continued support. The anticipated outcome by the end of the grant period is as follows: 4 newly completed PhD and 8 Masters degrees, prepared either for postdoctoral work or having submitted grant proposals for independent funding with appointment to the UPCH or other Peruvian university faculty. A focused group of highly experienced, funded U.S. and Peruvian investigators with priorities on research capacity building will provide mentorship focused on training at the Universidad Peruana Cayetano Heredia in Lima.

Public Health Relevance

This application directly addresses the RFA as we propose international training and research capacity building in globally important infectious diseases including malaria, leishmaniasis, leptospirosis, and Chagas Disease, focused at Universidad Peruana Cayetano Heredia in Lima, Peru. These diseases are of major international priority in public health.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW007120-08
Application #
8118970
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (51))
Program Officer
Sina, Barbara J
Project Start
2004-07-19
Project End
2014-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
8
Fiscal Year
2011
Total Cost
$198,154
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Gutierrez-Loli, Renzo; Orrego, Miguel A; Sevillano-Quispe, Oscar G et al. (2017) MicroRNAs in Taenia solium Neurocysticercosis: Insights as Promising Agents in Host-Parasite Interaction and Their Potential as Biomarkers. Front Microbiol 8:1905
Cowell, Annie N; Loy, Dorothy E; Sundararaman, Sesh A et al. (2017) Selective Whole-Genome Amplification Is a Robust Method That Enables Scalable Whole-Genome Sequencing of Plasmodium vivax from Unprocessed Clinical Samples. MBio 8:
Hupalo, Daniel N; Luo, Zunping; Melnikov, Alexandre et al. (2016) Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax. Nat Genet 48:953-8
Rosas-Aguirre, Angel; Gamboa, Dionicia; Manrique, Paulo et al. (2016) Epidemiology of Plasmodium vivax Malaria in Peru. Am J Trop Med Hyg 95:133-144
Jara, Marlene; Valencia, Braulio Mark; Adaui, Vanessa et al. (2016) Quantitative Kinetoplast DNA Assessment During Treatment of Mucosal Leishmaniasis as a Potential Biomarker of Outcome: A Pilot Study. Am J Trop Med Hyg 94:107-13
Lehmann, Jason S; Corey, Victoria C; Ricaldi, Jessica N et al. (2016) Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture Attenuation. Am J Trop Med Hyg 94:302-13
Fouts, Derrick E; Matthias, Michael A; Adhikarla, Haritha et al. (2016) What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira. PLoS Negl Trop Dis 10:e0004403
Torres, Katherine J; Castrillon, Carlos E; Moss, Eli L et al. (2015) Genome-level determination of Plasmodium falciparum blood-stage targets of malarial clinical immunity in the Peruvian Amazon. J Infect Dis 211:1342-51
Patra, Kailash P; Li, Fengwu; Carter, Darrick et al. (2015) Alga-produced malaria transmission-blocking vaccine candidate Pfs25 formulated with a human use-compatible potent adjuvant induces high-affinity antibodies that block Plasmodium falciparum infection of mosquitoes. Infect Immun 83:1799-808
Chuquiyauri, Raul; Molina, Douglas M; Moss, Eli L et al. (2015) Genome-Scale Protein Microarray Comparison of Human Antibody Responses in Plasmodium vivax Relapse and Reinfection. Am J Trop Med Hyg 93:801-9

Showing the most recent 10 out of 64 publications