Tuberculosis (TB) has emerged as an enormous public health problem in the independent and democratic country of Georgia, a former Soviet republic. High rates of multidrug resistant (MDR)-TB have been demonstrated in Georgia in large part through investigations carried out by Fogarty trainees supported by the Emory-Georgia TB Research Training Program (EGTB-RTP). TB control efforts are further challenged by the emergence of extensive drug resistant (XDR)-TB in Georgia. Considerable progress has been made in establishing a solid foundation to support TB research in Georgia over the past four years. This renewal application for the EGTB-RTP is submitted to obtain additional funding to build upon the achievements made in the first grant cycle and further expand the in-country TB research and public health infrastructure and capacity which will allow Georgian investigators to carry out internationally relevant TB-related research and translate research findings into practice and public policy in Georgia.
Specific aims of this application include: 1) To continue to build human resource capacity and enhance the research infrastructure for high quality TB-related research in Georgia by providing long, medium and short-term research training and research opportunities;this includes opportunities for research training in relevant laboratory, clinical, epidemiologic and social science TB-related research;2) To transition the focus of TB-related research training to in-country training in Georgia;3) To enhance and greatly expand the capacity to carry out TB-related translational research in Georgia (including Tl """"""""bench to beside"""""""" research and T2 and T3 """"""""bedside to community"""""""" research which includes Implementation Science research);4) To enhance in-country research ethics training in Georgia;and 5) To enhance opportunities for multidisciplinary TB-related research and collaboration among investigators and among several key institutions in Georgia including the National Center for Tuberculosis and Lung Disease/National TB Program;the National Center for Disease Control and Public Health;the Infectious Diseases, AIDS, and Clinical Immunology Research Center;and Tbilisi State Medical University.

Public Health Relevance

By building TB research capacity in Georgia, trainees will be able to enhance the public health infrastructure through translation of research into practice and public policy. In addition, they will be capable of conducting high quality internationally-recognized research including translational research and Implementation Science research. This will allow better targeting of funds from the Global Fund and other programs.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW007124-08
Application #
8122209
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (51))
Program Officer
Sina, Barbara J
Project Start
2004-09-27
Project End
2014-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
8
Fiscal Year
2011
Total Cost
$195,461
Indirect Cost
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
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Magee, M J; Darchia, L; Kipiani, M et al. (2017) Smoking behavior and beliefs about the impact of smoking on anti-tuberculosis treatment among health care workers. Int J Tuberc Lung Dis 21:1049-1055
Rosenthal, Alex; Gabrielian, Andrei; Engle, Eric et al. (2017) The TB Portals: an Open-Access, Web-Based Platform for Global Drug-Resistant-Tuberculosis Data Sharing and Analysis. J Clin Microbiol 55:3267-3282
Kempker, Russell R; Heinrichs, M Tobias; Nikolaishvili, Ketino et al. (2017) Lung Tissue Concentrations of Pyrazinamide among Patients with Drug-Resistant Pulmonary Tuberculosis. Antimicrob Agents Chemother 61:
Guglielmetti, L; Hewison, C; Avaliani, Z et al. (2017) Examples of bedaquiline introduction for the management of multidrug-resistant tuberculosis in five countries. Int J Tuberc Lung Dis 21:167-174
Chakravorty, Soumitesh; Simmons, Ann Marie; Rowneki, Mazhgan et al. (2017) The New Xpert MTB/RIF Ultra: Improving Detection of Mycobacterium tuberculosis and Resistance to Rifampin in an Assay Suitable for Point-of-Care Testing. MBio 8:
Kempker, Russell R; Peloquin, Charles A; Blumberg, Henry M et al. (2017) Reply to Srivastava et al., ""pH Conditions under Which Pyrazinamide Works in Humans"". Antimicrob Agents Chemother 61:
Allana, Salim; Shashkina, Elena; Mathema, Barun et al. (2017) pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia. Emerg Infect Dis 23:491-495
Vashakidze, Sergo; Despuig, Albert; Gogishvili, Shota et al. (2017) Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia. Int J Infect Dis 56:200-207
Abutidze, A; Bolokadze, N; Chkhartishvili, N et al. (2016) INCIDENCE OF TUBERCULOSIS AMONG HIV/HCV CO-INFECTED PATIENTS RECEIVING HEPATITIS C TREATMENT WITH PEGYLATED INTERFERON AND RIBAVIRIN IN GEORGIA. Georgian Med News :10-5

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