Tuberculosis (TB) has emerged as an enormous public health problem in the independent and democratic country of Georgia, a former Soviet republic. High rates of multidrug resistant (MDR)-TB have been demonstrated in Georgia in large part through investigations carried out by Fogarty trainees supported by the Emory-Georgia TB Research Training Program (EGTB-RTP). TB control efforts are further challenged by the emergence of extensive drug resistant (XDR)-TB in Georgia. Considerable progress has been made in establishing a solid foundation to support TB research in Georgia over the past four years. This renewal application for the EGTB-RTP is submitted to obtain additional funding to build upon the achievements made in the first grant cycle and further expand the in-country TB research and public health infrastructure and capacity which will allow Georgian investigators to carry out internationally relevant TB-related research and translate research findings into practice and public policy in Georgia.
Specific aims of this application include: 1) To continue to build human resource capacity and enhance the research infrastructure for high quality TB-related research in Georgia by providing long, medium and short-term research training and research opportunities;this includes opportunities for research training in relevant laboratory, clinical, epidemiologic and social science TB-related research;2) To transition the focus of TB-related research training to in-country training in Georgia;3) To enhance and greatly expand the capacity to carry out TB-related translational research in Georgia (including Tl """"""""bench to beside"""""""" research and T2 and T3 """"""""bedside to community"""""""" research which includes Implementation Science research);4) To enhance in-country research ethics training in Georgia;and 5) To enhance opportunities for multidisciplinary TB-related research and collaboration among investigators and among several key institutions in Georgia including the National Center for Tuberculosis and Lung Disease/National TB Program;the National Center for Disease Control and Public Health;the Infectious Diseases, AIDS, and Clinical Immunology Research Center;and Tbilisi State Medical University.

Public Health Relevance

By building TB research capacity in Georgia, trainees will be able to enhance the public health infrastructure through translation of research into practice and public policy. In addition, they will be capable of conducting high quality internationally-recognized research including translational research and Implementation Science research. This will allow better targeting of funds from the Global Fund and other programs.

National Institute of Health (NIH)
Fogarty International Center (FIC)
International Research Training Grants (D43)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (51))
Program Officer
Sina, Barbara J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Emory University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Comeau, Dawn L; Mishkin, Kathryn; Tukvadze, Nestani et al. (2018) Mentoring in Global Health: Formative Evaluation of Tuberculosis Research Training Programs in Ethiopia and Georgia. Am J Trop Med Hyg 99:565-577
Collins, Jeffrey M; Walker, Douglas I; Jones, Dean P et al. (2018) High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans. PLoS One 13:e0205398
Baliashvili, D; Kempker, R R; Blumberg, H M et al. (2018) A population-based tuberculosis contact investigation in the country of Georgia. Public Health Action 8:110-117
Kempker, Russell R; Heinrichs, M Tobias; Nikolaishvili, Ketino et al. (2018) A comparison of linezolid lung tissue concentrations among patients with drug-resistant tuberculosis. Eur Respir J 51:
Heinrichs, M Tobias; Vashakidze, Sergo; Nikolaishvili, Ketino et al. (2018) Moxifloxacin target site concentrations in patients with pulmonary TB utilizing microdialysis: a clinical pharmacokinetic study. J Antimicrob Chemother 73:477-483
Efsen, A M W; Schultze, A; Miller, R F et al. (2018) Management of MDR-TB in HIV co-infected patients in Eastern Europe: Results from the TB:HIV study. J Infect 76:44-54
Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017; Ahmad, Nafees; Ahuja, Shama D et al. (2018) Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet 392:821-834
Graciaa, D S; Machaidze, M; Kipiani, M et al. (2018) A survey of the tuberculosis physician workforce in the country of Georgia. Int J Tuberc Lung Dis 22:1286-1292
Kempker, Russell R; Tukvadze, Nestani; Sthreshley, Lisa et al. (2018) The Impact of a Fogarty International Center-Supported Tuberculosis Research Training Program in the Country of Georgia. Am J Trop Med Hyg 98:1069-1074
Dorman, Susan E; Schumacher, Samuel G; Alland, David et al. (2018) Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study. Lancet Infect Dis 18:76-84

Showing the most recent 10 out of 83 publications