This is a competitive renewal application to support a training program begun in Uganda in 2000. The focus of our program has been consistent, with concentration on training in malaria research in Uganda. Our philosophy for training is to emphasize research, with trainees participating in both hands-on mentored malaria research and formal training programs designed to complement the hands on-training and facilitate growth of trainees into independent researchers. We believe that our program has been highly successful, as evidenced by the accomplishments of our trainees. About 50 Ugandan junior scientists have received advanced training, mostly at the Masters level, 13 of these trainees have so far advanced to PhD training, and our more senior trainees are advancing to academic positions in Uganda. Our trainees have authored ~250 papers during or after their training, with 61 first-author papers to date. We are gratified by the successes of our trainees. However, the need for training in malaria research in Uganda remains great. Thus, we feel that it is appropriate to continue our program, building upon our initial success and upon the structures for training that we have established. With maturation of our malaria research program in Uganda and an increased supply of highly qualified training applicants, we plan some changes to our program, in particular increased emphasis on higher level training. We now plan 5 training tracks: 1) short-term training outside Uganda; 2) Masters training at Makerere University; 3) advanced Masters training at UCSF; 4) sandwich PhD training at Makerere University; and 5) postdoctoral training. We are excited about our success to date with both training and research on malaria in Uganda, and we anticipate that continued funding will allow continued progress toward the establishment of cutting-edge independent research capacity in this country and also toward the control and elimination of malaria.

Public Health Relevance

Our program has offered training to Ugandan scientists in malaria research since 2000. With continuation of this program, we will provide short-term, Masters-level, PhD, and postdoctoral training, all linked to mentored research projects. Our goal is to improve research capacity in Uganda to facilitate the control and eventual elimination of malaria.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW007375-14
Application #
9419205
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Sina, Barbara J
Project Start
2005-09-16
Project End
2020-01-31
Budget Start
2018-02-01
Budget End
2019-01-31
Support Year
14
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Walakira, Andrew; Tukwasibwe, Stephen; Kiggundu, Moses et al. (2017) Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda. Infect Genet Evol 55:281-287
Ssewanyana, Isaac; Arinaitwe, Emmanuel; Nankabirwa, Joaniter I et al. (2017) Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda. Malar J 16:67
Cooper, Roland A; Conrad, Melissa D; Watson, Quentin D et al. (2015) Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays. Antimicrob Agents Chemother 59:5061-4
Tumwebaze, Patrick; Conrad, Melissa D; Walakira, Andrew et al. (2015) Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children. Antimicrob Agents Chemother 59:3018-30
Nankabirwa, Joaniter I; Wandera, Bonnie; Amuge, Pauline et al. (2014) Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trial. Clin Infect Dis 58:1404-12
Kakuru, Abel; Achan, Jane; Muhindo, Mary K et al. (2014) Artemisinin-based combination therapies are efficacious and safe for treatment of uncomplicated malaria in HIV-infected Ugandan children. Clin Infect Dis 59:446-53
Tukwasibwe, Stephen; Mugenyi, Levi; Mbogo, George W et al. (2014) Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda. J Infect Dis 210:154-7
Nankoberanyi, Sheila; Mbogo, George W; LeClair, Norbert P et al. (2014) Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda. Malar J 13:95
Mbogo, George W; Nankoberanyi, Sheila; Tukwasibwe, Stephen et al. (2014) Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda. Am J Trop Med Hyg 91:54-61
Nankabirwa, Joaniter; Wandera, Bonnie; Kiwanuka, Noah et al. (2013) Asymptomatic Plasmodium infection and cognition among primary schoolchildren in a high malaria transmission setting in Uganda. Am J Trop Med Hyg 88:1102-8

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