This is a competitive renewal application to support a training program begun in Uganda in 2000. The focus of our program has been consistent, with concentration on training in malaria research in Uganda. Our philosophy for training is to emphasize research, with trainees participating in both hands-on mentored malaria research and formal training programs designed to complement the hands on-training and facilitate growth of trainees into independent researchers. We believe that our program has been highly successful, as evidenced by the accomplishments of our trainees. About 50 Ugandan junior scientists have received advanced training, mostly at the Masters level, 13 of these trainees have so far advanced to PhD training, and our more senior trainees are advancing to academic positions in Uganda. Our trainees have authored ~250 papers during or after their training, with 61 first-author papers to date. We are gratified by the successes of our trainees. However, the need for training in malaria research in Uganda remains great. Thus, we feel that it is appropriate to continue our program, building upon our initial success and upon the structures for training that we have established. With maturation of our malaria research program in Uganda and an increased supply of highly qualified training applicants, we plan some changes to our program, in particular increased emphasis on higher level training. We now plan 5 training tracks: 1) short-term training outside Uganda; 2) Masters training at Makerere University; 3) advanced Masters training at UCSF; 4) sandwich PhD training at Makerere University; and 5) postdoctoral training. We are excited about our success to date with both training and research on malaria in Uganda, and we anticipate that continued funding will allow continued progress toward the establishment of cutting-edge independent research capacity in this country and also toward the control and elimination of malaria.

Public Health Relevance

Our program has offered training to Ugandan scientists in malaria research since 2000. With continuation of this program, we will provide short-term, Masters-level, PhD, and postdoctoral training, all linked to mentored research projects. Our goal is to improve research capacity in Uganda to facilitate the control and eventual elimination of malaria.

National Institute of Health (NIH)
Fogarty International Center (FIC)
International Research Training Grants (D43)
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Special Emphasis Panel (ZRG1)
Program Officer
Sina, Barbara J
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Mpimbaza, Arthur; Walakira, Andrew; Ndeezi, Grace et al. (2018) Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study. PLoS One 13:e0203229
Mpimbaza, Arthur; Ndeezi, Grace; Katahoire, Anne et al. (2017) Demographic, Socioeconomic, and Geographic Factors Leading to Severe Malaria and Delayed Care Seeking in Ugandan Children: A Case-Control Study. Am J Trop Med Hyg 97:1513-1523
Walakira, Andrew; Tukwasibwe, Stephen; Kiggundu, Moses et al. (2017) Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda. Infect Genet Evol 55:281-287
Tukwasibwe, Stephen; Tumwebaze, Patrick; Conrad, Melissa et al. (2017) Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. Malar J 16:125
Rosenthal, Philip J; Bausch, Daniel G; Higgs, Stephen et al. (2017) Evidence-Based Policies on Migration and Global Health are Essential to Maintain the Health of Those Inside and Outside the United States. Am J Trop Med Hyg 96:5-6
Tumwebaze, Patrick; Tukwasibwe, Stephen; Taylor, Aimee et al. (2017) Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda. J Infect Dis 215:631-635
Asua, Victor; Tukwasibwe, Stephen; Conrad, Melissa et al. (2017) Plasmodium Species Infecting Children Presenting with Malaria in Uganda. Am J Trop Med Hyg 97:753-757
Ssewanyana, Isaac; Arinaitwe, Emmanuel; Nankabirwa, Joaniter I et al. (2017) Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda. Malar J 16:67
Nankabirwa, Joaniter I; Conrad, Melissa D; Legac, Jennifer et al. (2016) Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity. Antimicrob Agents Chemother 60:5649-54
Cooper, Roland A; Conrad, Melissa D; Watson, Quentin D et al. (2015) Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays. Antimicrob Agents Chemother 59:5061-4

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