I propose to develop a highly innovative patient-specific MRI-based heart modeling environment that represents cardiac functions from molecular processes to electrophysiological and electromechanical interactions at the organ level. I term this environment "virtual electrophysiology lab", and propose to translate it into th clinic and apply it to the non-invasive diagnosis and treatment of heart rhythm and contractile disorders in patients with structural heart disease. This pioneering effort offers to integrate, fo the first time, computational modeling of the heart, traditionally a basic-science discipline, withn the milieu of contemporary patient care. The robust and inexpensive non-invasive approaches for individualized arrhythmia risk stratification and guidance of electrophysiological therapies proposed here will lead to optimized therapy delivery and reduction in health care costs, and will have a dramatic personal, medical and economic impact on society. This project seeks to shift the paradigm of cardiac patient care by utilizing the virtual electrophysiology laboratory environment in three applications pertinent to patients with myocardial infarction: 1. Noninvasive prediction of the optimal ablation targets for infarct-related ventricular tachycardia. The vital electrophysiology lab will be used to accurately identify the optimal targets of ablation in each patient heart non-invasively prior to the clinical procedure. Delivery of ablation will then be swit and precise, eradicating all infarct-related ventricular tachycardias with minimum lesion sizes. This will result in a dramatic improvement in the efficacy of and tolerance for the therapy, as wel as in reduction of post-procedure complications. 2. Arrhythmia risk assessment to determine the need for implantable defibrillator deployment. Personalized simulations of arrhythmia inducibility will be used as a noninvasive, inexpensive, and risk-free surrogate for a clinical elect

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
NIH Director’s Pioneer Award (NDPA) (DP1)
Project #
1DP1HL123271-01
Application #
8561487
Study Section
Special Emphasis Panel (ZRG1-BCMB-N (50))
Program Officer
Lee, Albert
Project Start
2013-09-25
Project End
2018-07-31
Budget Start
2013-09-25
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$810,000
Indirect Cost
$310,000
Name
Johns Hopkins University
Department
Biostatistics & Other Math Sci
Type
Schools of Engineering
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Trayanova, Natalia A; Rantner, Lukas J (2014) New insights into defibrillation of the heart from realistic simulation studies. Europace 16:705-13
Trayanova, Natalia A (2014) Virtual 3D heart models to aid pacemaker implantation in children. Future Cardiol 10:5-8
Trayanova, Natalia A; Boyle, Patrick M (2014) Advances in modeling ventricular arrhythmias: from mechanisms to the clinic. Wiley Interdiscip Rev Syst Biol Med 6:209-24
Wright, Peter T; Nikolaev, Viacheslav O; O'Hara, Thomas et al. (2014) Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling. J Mol Cell Cardiol 67:38-48
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Hu, Yuxuan; Gurev, Viatcheslav; Constantino, Jason et al. (2014) Optimizing cardiac resynchronization therapy to minimize ATP consumption heterogeneity throughout the left ventricle: a simulation analysis using a canine heart failure model. Heart Rhythm 11:1063-9