Mark J. Schnitzer, Ph.D., is an assistant professor of biological sciences and applied physics at Stanford University. He received a Ph.D. in physics from Princeton University in 1999. Schnitzer's goal is to understand the large-scale dynamics of neural circuits. Toward this end, his lab has invented a number of minimally invasive brain-imaging techniques based on fiber-optics and has been investigating mammalian neural circuits underlying locomotor coordination using a multidisciplinary approach that combines imaging, behavioral, anatomical, and computational studies. With his Pioneer Award, Schnitzer is pursuing an understanding of neural dynamics in the fruit fly, with a focus on neural circuits involved in sensorimotor decision-making. His multidisciplinary approach makes use of new technology for automated, laser-based tissue dissection and brain imaging in large numbers of flies, allowing him to perform innovative analyses of the biological basis for decision-making. Schnitzer's honors include fellowships from the Beckman, Klingenstein, Sloan, and Packard foundations and a Presidential Early Career Award for Scientists and Engineers.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
NIH Director’s Pioneer Award (NDPA) (DP1)
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Special Emphasis Panel (ZGM1-NDPA-G (P2))
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Zhang, Yantian
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Stanford University
Schools of Arts and Sciences
United States
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Savall, Joan; Ho, Eric Tatt Wei; Huang, Cheng et al. (2015) Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation. Nat Methods 12:657-660
Gong, Yiyang; Huang, Cheng; Li, Jin Zhong et al. (2015) High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor. Science 350:1361-6
Gong, Yiyang (2015) The evolving capabilities of rhodopsin-based genetically encoded voltage indicators. Curr Opin Chem Biol 27:84-9
Gong, Yiyang; Wagner, Mark J; Zhong Li, Jin et al. (2014) Imaging neural spiking in brain tissue using FRET-opsin protein voltage sensors. Nat Commun 5:3674
Chen, Jerry L; Andermann, Mark L; Keck, Tara et al. (2013) Imaging neuronal populations in behaving rodents: paradigms for studying neural circuits underlying behavior in the mammalian cortex. J Neurosci 33:17631-40
Deisseroth, Karl; Schnitzer, Mark J (2013) Engineering approaches to illuminating brain structure and dynamics. Neuron 80:568-77
Ziv, Yaniv; Burns, Laurie D; Cocker, Eric D et al. (2013) Long-term dynamics of CA1 hippocampal place codes. Nat Neurosci 16:264-6
Fitzgerald, James E; Lu, Ju; Schnitzer, Mark J (2012) Estimation theoretic measure of resolution for stochastic localization microscopy. Phys Rev Lett 109:048102
Fitzgerald, James E; Katsov, Alexander Y; Clandinin, Thomas R et al. (2011) Symmetries in stimulus statistics shape the form of visual motion estimators. Proc Natl Acad Sci U S A 108:12909-14
Wilt, Brian A; Burns, Laurie D; Wei Ho, Eric Tatt et al. (2009) Advances in light microscopy for neuroscience. Annu Rev Neurosci 32:435-506