DP2GM105453?01 MYONG, SUA GRANT TRANSFER APPLICATION For all transfer applications include also a statement indicating whether the overallresearch plans/aims have changed from the original submission, and, if so, provideupdated information.The overall research plans/aims have not changed from the original submission.
DP2GM105453?01 MYONG; SUA GRANT TRANSFER APPLICATION PROJECT NARRATIVEOur proposal involves developing novel single molecule platforms which allow quantitative andstepwise analysis of RNAi pathway and opens a new way of assessing and predicting siRNAefficacy. When engineered into a device; such technique can be adopted by research laboratoriesand clinical practices for designing siRNA for high silencing potency for disease treatment.
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| Koh, Hye Ran; Ghanbariniaki, Amirhossein; Myong, Sua (2017) RNA stem structure governs coupling of dicing and gene silencing in RNA interference. Proc Natl Acad Sci U S A 114:E10349-E10358 |
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