In current drug development, there exist huge gaps in translating activity in the preclinical screening models into desirable clinical outcomes in humans. In this project titled "Rapid reverse translational drug repositioning: novel computational approaches, unique data, and broad implications," we propose to develop a novel drug discovery strategy that directly translates observed phenotypic perturbations caused by drugs or diseases in human bodies into novel disease treatments in humans (direct human ->human translation), and retrospectively corroborates novel drug indications using large amounts of patient electronic health record (EHR) data. In this way, we can minimize the translational gap between pre-clinical testing results in animal models and clinical outcomes in humans in current drug development.

Public Health Relevance

In this project titled Rapid reverse translational drug repositioning: novel computational approaches, unique data, and broad implications, we propose to develop a novel drug discovery strategy that directly translates observed phenotypic perturbations caused by drugs or diseases in human bodies into novel disease treatments in humans (direct human ->human translation). In this way, we can minimize the translational gap between pre-clinical testing results in animal models and clinical outcomes in humans, which is a significant problem in current drug development.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
NIH Director’s New Innovator Awards (DP2)
Project #
1DP2HD084068-01
Application #
8757089
Study Section
Special Emphasis Panel (ZRG1-MOSS-C (56))
Program Officer
Tsilou, Katerina
Project Start
2014-09-15
Project End
2019-08-31
Budget Start
2014-09-15
Budget End
2019-08-31
Support Year
1
Fiscal Year
2014
Total Cost
$2,377,500
Indirect Cost
$877,500
Name
Case Western Reserve University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106