Methamphetamine (MA) abuse is an international public health concern. Individuals dependent on MA suffer from disturbances in emotional response and abnormalities in behavior indicative of emotional dysregulation. The ability to perceive and evaluate emotional stimuli and to consciously regulate emotional response is dependent on the integrity of specific brain regions and their interconnections.
The first aim of this project is to identify the brain regions and the neural networks that show dysfunction during the response to negative emotional stimuli.
The second aim i s to identify abnormalities in brain function that occur while attempting to use cognitive reappraisal to decrease the strength of the negative emotion elicited. Cognitive reappraisal is a type of emotion regulation strategy taught in cognitive behavioral therapy; currently, behavioral therapy is the only successful treatment for MA dependence. We will use functional magnetic resonance imaging (fMRI) to evaluate brain function and images from the International Affective Picture System (IAPS) to elicit negative emotions during the first 4-7 days of MA abstinence, the time during treatment when most are vulnerable to relapse. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Individual Predoctoral NRSA for M.D./Ph.D. Fellowships (ADAMHA) (F30)
Project #
5F30DA021961-02
Application #
7354834
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Stanford, Laurence
Project Start
2007-03-01
Project End
2010-02-28
Budget Start
2008-03-01
Budget End
2009-02-28
Support Year
2
Fiscal Year
2008
Total Cost
$38,289
Indirect Cost
Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Payer, Doris E; Baicy, Kate; Lieberman, Matthew D et al. (2012) Overlapping neural substrates between intentional and incidental down-regulation of negative emotions. Emotion 12:229-35
Tabibnia, Golnaz; Monterosso, John R; Baicy, Kate et al. (2011) Different forms of self-control share a neurocognitive substrate. J Neurosci 31:4805-10
Baicy, Kate; London, Edythe D; Monterosso, John et al. (2007) Leptin replacement alters brain response to food cues in genetically leptin-deficient adults. Proc Natl Acad Sci U S A 104:18276-9