The vast majority of HIV spread in sub-Saharan Africa occurs through heterosexual contact;when a new patient is discovered it is critically important to find sexual partners who require evaluation for therapy or prevention strategies. Partner notification involves informing the sexual partners of HIV-positive persons that they have been exposed and encouraging them to seek counseling, testing and other prevention and treatment services. Providing counseling, testing, and early care to this very high risk population is crucially important for HIV prevention and mitigation. However, strategies to accomplish these goals in low-income countries have not been well studied and optimized. This project's objective is to increase understanding of HIV partner notification in sub-Saharan Africa by identifying the notification methods most likely to result in partner uptake of HIV counseling and testing and the community-level factors that influence HIV counseling and testing rates. Understanding both the individual and structural factors that influence HIV testing, including the context in which individuals are more likely to respond to partner notification strategies, will suggest future patient-based and community- based interventions for increasing the proportion of the population who are aware of their HIV status.
The specific aims of this project are to identify (1)which method of partner notification - patient referral, contract referral, or provider referral ~ results in the highest rate of partner referral and partner HIV-testing uptake;(2) the proportion of previously undiagnosed HIV cases identified among partners for each method of partner notification;and (3) community-level factors influencing HIV counseling and testing uptake. Public Health Relevance: We will conduct a randomized trial of HIV partner notification in an STI clinic in Malawi to determine the rates of counseling, testing and new HIV diagnoses among partners. Community-level factors will be identified through the 2008 Malawi Population and Housing Census, and a multi-level random-effects model will be used to determine their relative association with HIV counseling and testing rates. This research will be the first to provide important local evidence on the most effective method of partner notification in a sub- Saharan African STI clinic patient population.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Individual Predoctoral NRSA for M.D./Ph.D. Fellowships (ADAMHA) (F30)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-AARR-H (22))
Program Officer
Stoff, David M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Public Health & Prev Medicine
Schools of Public Health
Chapel Hill
United States
Zip Code
Shaboltas, Alla V; Skochilov, Roman V; Brown, Lillian B et al. (2013) The feasibility of an intensive case management program for injection drug users on antiretroviral therapy in St. Petersburg, Russia. Harm Reduct J 10:15
Brown, Lillian B; Miller, William C; Kamanga, Gift et al. (2012) Predicting partner HIV testing and counseling following a partner notification intervention. AIDS Behav 16:1148-55
Brown, Lillian B; Miller, William C; Kamanga, Gift et al. (2011) HIV partner notification is effective and feasible in sub-Saharan Africa: opportunities for HIV treatment and prevention. J Acquir Immune Defic Syndr 56:437-42