The proposed studies aim to clarify the cognitive and neural mechanisms that underlie the ways in which both young and older adults strategically enhance memory for words that are arbitrarily designated as more valuable to remember. Prior findings imply that the ability to selectively direct memory encoding is preserved, or even enhanced, in old age. In our value-directed remembering (VDR) paradigm, participants are shown a value cue for each item, followed by a word. Five lists are presented in the scanner, with a free recall test after each list, and feedback on the point total after each test. The use o multiple study-test cycles allows participants to develop strategies to optimize encoding.
Specific Aim 1 A is to determine which brain areas are associated with successful encoding of valuable words in older adults using fMRI. We have collected fMRI data in the VDR paradigm with 20 young adult participants, and preliminary analyses show that, in young adults, the ventrolateral prefrontal cortex (VLPFC) is important in successful encoding of high-value words. By testing older adults on the VDR paradigm with neuroimaging, we could find evidence for either a contralateral compensation hypothesis (Cabeza, 2002), or for a different theory of compensation that focuses on subregions of the PFC (Rajah &D'Esposito, 2005). Because this is a task in which older adults perform well, we expect to gain important insight into both the cognitive and neural mechanisms underlying how healthy older adults compensate for normal degradation in the brain systems supporting memory.
Specific Aim 1 B is to characterize patterns of functional and structural connectivity associated with selective encoding. In young adults, the memory benefit for high value words, relative to low-value words, correlates with the degree of increased functional connectivity between L VLPFC and L lateral posterior temporal cortex during encoding of high value words. The degree of memory benefit for high-value words also correlates with the degree of increased connectivity between L hippocampus and L VTA during the cue that precedes each to-be-learned word. We plan to examine whether value-related enhancement of memory in older adults involves one or both of these mechanisms, or whether some other mechanism is critical in older adults.
Specific Aim 2 is to characterize whether enhanced memory for high-value items leads to enhanced recollection or familiarity. In young adults, it appears that value enhances only recollection. Recollection tends to be more impaired than familiarity in older adults, however, so it is unclear which component would mediate the enhancement of encoding for high-value items in older adults. The proposed training plan will provide me with important experience collecting and analyzing neuroimaging data in older adults, as well as experience using cutting edge methods to analyze functional and structural connectivity. By providing insight into the mechanisms of compensatory processing, this project will allow for the development of better training programs for healthy older adults, and for a better understanding of pathological aging.

Public Health Relevance

Efficient use of memory is important, particularly for older adults, and past work has shown that in fact, older adults are good at remembering the things that are defined as being important at the expense of things that are designated as less important. This project examines the patterns of neural activity that allow healthy older adults to be able to compensate for the reductions in cognitive abilities that are a natural part of the agin process. This research could lead to training programs that help healthy older adults improve their cognitive performance, and could also lead to a better understanding of why some people age well while others do not.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Predoctoral Individual National Research Service Award (F31)
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Special Emphasis Panel (ZRG1-F02B-D (20))
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King, Jonathan W
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University of California Los Angeles
Other Domestic Higher Education
Los Angeles
United States
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Cohen, Michael S; Rissman, Jesse; Hovhannisyan, Mariam et al. (2017) Free recall test experience potentiates strategy-driven effects of value on memory. J Exp Psychol Learn Mem Cogn 43:1581-1601
Cohen, Michael S; Rissman, Jesse; Suthana, Nanthia A et al. (2016) Effects of aging on value-directed modulation of semantic network activity during verbal learning. Neuroimage 125:1046-1062
Cohen, Michael S; Rissman, Jesse; Suthana, Nanthia A et al. (2014) Value-based modulation of memory encoding involves strategic engagement of fronto-temporal semantic processing regions. Cogn Affect Behav Neurosci 14:578-92