The hippocampus has a well established role in learning and memory (Scoville & Milner, 1957; Squire, 1992), and hippocampal damage is primarily responsible for the memory impairments resulting from a variety of neurological conditions such as Alzheimer's disease, epilepsy and stroke. In vivo electrophysiological studies of the hippocampus have revealed some salient activity patterns. Specifically, hippocampal cells in both rodents and humans fire in a spatially selective manner (O'Keefe and Dostrovsky, 1971; O'Keefe and Recce, 1993; Ekstrom et al., 2003, 2005). Both the firing-rate (rate code) and spike-timing (temporal code) contain information about the spatial environment. However, the cellular and circuit mechanisms that give rise to the hippocampal rate and temporal codes are still not well understood, and little is known about how inhibition shapes these hippocampal activity patterns. I will combine in vivo and in vitro experiments with computational modeling to investigate the inhibitory mechanisms governing the hippocampal temporal code. Using such an understanding, we can precisely pinpoint what properties of the circuit are crucial for hippocampal function. This can point us towards novel targets for treating clinical ailments resulting from hippocampal damage. Relevance: The human hippocampus is important for learning and memory but it is prone to damage: strokes, dementias (including Alzheimer's disease), epilepsies and hypoxia can all lead to hippocampal damage, and subsequent learning and memory difficulties. By understanding the neural code of the hippocampus we can precisely pinpoint which of its cells and circuits are crucial for learning and memory. This can point us towards novel targets for treating problems resulting from hippocampal damage. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31MH081477-01A1
Application #
7408742
Study Section
Special Emphasis Panel (ZRG1-F02A-A (20))
Program Officer
Curvey, Mary F
Project Start
2007-11-16
Project End
2010-08-15
Budget Start
2007-11-16
Budget End
2008-11-15
Support Year
1
Fiscal Year
2007
Total Cost
$34,572
Indirect Cost
Name
Brown University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Ahmed, Omar J; Mehta, Mayank R (2012) Running speed alters the frequency of hippocampal gamma oscillations. J Neurosci 32:7373-83
Ahmed, Omar J; Mehta, Mayank R (2009) The hippocampal rate code: anatomy, physiology and theory. Trends Neurosci 32:329-38
Ahmed, Omar Jamil; McFarland, James; Kumar, Arvind (2008) Reactivation in ventral striatum during hippocampal ripples: evidence for the binding of reward and spatial memories? J Neurosci 28:9895-7