The current proposal is aimed at developing a novel neurobiological marker based on patterns of whole-brain functional connectivity during implicit and subliminal threat-related facial emotion perception to aid the diagnosis and assessment of treatment response in social anxiety (SAD) and panic disorder (PD). The following Specific Aims are proposed:
Specific Aim 1). Develop, apply and validate an approach to estimate the large-scale functional networks of implicit and subliminal threat-related and ambiguous facial emotion processing in a healthy control subject pool. We will perform this by first testing whether large-scale partial correlations measured during a particular condition (i.e. presentation of visible or invisible fearful and neutral faces) can be used as features to predict the stimulus type presented during the condition (Sub-aim 1a). We will then test whether the most informative features for predicting fearful vs. neutral face conditions are connections among primarily limbic and paralimbic nodes, and that the most informative features in predicting neutral vs. resting states conditions are connections among primarily attention, motor and sensory related regions (Sub-aim 1b).
Specific Aim 2). Determine whether the approach developed in SA1 may have potential clinical application towards the diagnosis and treatment of SAD and PD. We will perform this by testing whether the above functional networks are informative brain signatures that can be used to discriminate between healthy controls, SAD and PD subjects (Sub-aim 2a). We will also test whether the approach can be used to determine the particular sub-networks that are aberrant in SAD and PD (Sub-aim 2b).

Public Health Relevance

The proposed approach may contribute toward the development of effective biomarkers in the diagnosis of SAD and PD. It may also identify the functional connections whose patterns differ between control and SAD, control and PD, and SAD and PD. This would contribute to our understanding of and aid in the development of therapies for these distinct anxiety disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31MH088104-03
Application #
8262402
Study Section
Special Emphasis Panel (ZRG1-F01-L (20))
Program Officer
Rubio, Mercedes
Project Start
2010-06-07
Project End
2013-06-06
Budget Start
2012-06-07
Budget End
2013-06-06
Support Year
3
Fiscal Year
2012
Total Cost
$38,180
Indirect Cost
Name
Columbia University (N.Y.)
Department
Physiology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Pantazatos, Spiro P; Talati, Ardesheer; Schneier, Franklin R et al. (2014) Reduced anterior temporal and hippocampal functional connectivity during face processing discriminates individuals with social anxiety disorder from healthy controls and panic disorder, and increases following treatment. Neuropsychopharmacology 39:425-34
Hamberger, Marla J; Habeck, Christian G; Pantazatos, Spiro P et al. (2014) Shared space, separate processes: Neural activation patterns for auditory description and visual object naming in healthy adults. Hum Brain Mapp 35:2507-20
Talati, Ardesheer; Pantazatos, Spiro P; Schneier, Franklin R et al. (2013) Gray matter abnormalities in social anxiety disorder: primary, replication, and specificity studies. Biol Psychiatry 73:75-84
Karten, Ariel; Pantazatos, Spiro P; Khalil, David et al. (2013) Dynamic coupling between the lateral occipital-cortex, default-mode, and frontoparietal networks during bistable perception. Brain Connect 3:286-93
Pantazatos, Spiro P (2013) Prediction of individual season of birth using MRI. Neuroimage 88C:61-68
Pantazatos, Spiro P; Talati, Ardesheer; Pavlidis, Paul et al. (2012) Decoding unattended fearful faces with whole-brain correlations: an approach to identify condition-dependent large-scale functional connectivity. PLoS Comput Biol 8:e1002441
Lai, Grace; Pantazatos, Spiro P; Schneider, Harry et al. (2012) Neural systems for speech and song in autism. Brain 135:961-75