Since the time of Kraepelin (1919) and Bleuler (1950) nearly every description of schizophrenia cognitive dysfunction highlights impairments in attention, yet the locus of this deficit is not well understood. One prominent model proposes that the locus of schizophrenia attentional dysfunction is due to an abnormality in the memory representations that we activate to control our attention (i.e., attentional guidance). Another leading model proposes that the neural mechanism important for shifting perceptual attention itself is damaged (i.e., input selection). In this project, I will use visual search tasks and noninvasive electrophysiological methods to test the competing predictions of these models of cognitive dysfunction. My analyses will focus on the relationships between visual working memory, long-term memory, and shifts of perceptual attention during both the proactive period of information processing prior to the behavioral response and the reactive period after an error. Additionally, I will combine electrophysiological methods with noninvasive electrical stimulation to determine whether it is possible to change how schizophrenia patients control and use attention during visual search. The primary research goal is to take the basic neuroscientific tools and insights for tracking the use of top-down control signals in healthy individuals and use them to deepen our understanding of the fundamental cognitive deficits in schizophrenia. The long-term goal is to develop interventions to improve cognitive functioning in these patients. My primary training goal is to become an independent investigator fully competent in performing translational neuroscience with clinical populations. I will meet these goals through targeted coursework, independent reading series, close supervision by my sponsors, building new collaborations with faculty at Vanderbilt University and Columbia University, and continued research. This translational research-training program will prepare me for my career objective of running my own laboratory at a top-tier research university.

Public Health Relevance

The potential contributions of this research include elucidating cognitive models of schizophrenia cognitive dysfunction and developing tools for the temporary remediation of cognitive control impairments in schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31MH102042-01A1
Application #
8717037
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Chavez, Mark
Project Start
2014-09-01
Project End
2017-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37212
Reinhart, Robert M G; Xiao, Wenxi; McClenahan, Laura J et al. (2016) Electrical Stimulation of Visual Cortex Can Immediately Improve Spatial Vision. Curr Biol 26:1867-72
Reinhart, Robert M G; McClenahan, Laura J; Woodman, Geoffrey F (2016) Attention's Accelerator. Psychol Sci 27:790-8
Reinhart, Robert M G; Woodman, Geoffrey F (2015) The surprising temporal specificity of direct-current stimulation. Trends Neurosci 38:459-61
Reinhart, Robert M G; Woodman, Geoffrey F (2015) Enhancing long-term memory with stimulation tunes visual attention in one trial. Proc Natl Acad Sci U S A 112:625-30
Reinhart, Robert M G; McClenahan, Laura J; Woodman, Geoffrey F (2015) Visualizing Trumps Vision in Training Attention. Psychol Sci 26:1114-22
Reinhart, Robert M G; Zhu, Julia; Park, Sohee et al. (2015) Synchronizing theta oscillations with direct-current stimulation strengthens adaptive control in the human brain. Proc Natl Acad Sci U S A 112:9448-53
Reinhart, Robert M G; Zhu, Julia; Park, Sohee et al. (2015) Medial-Frontal Stimulation Enhances Learning in Schizophrenia by Restoring Prediction Error Signaling. J Neurosci 35:12232-40