Abstract

PAX6 is a transcriptional activator containing two DNA binding motifs, the paired domain and the paired-type homeodomain. Both the gene and the expression pattern are highly conserved from insects to human. Pax-6 appears to be a master control gene for eye development in both vertebrates and invertebrates. However, in contrast to the numerous number of transcription factors identified in eye development, no PAX6 target genes have been identified that an generate embryonic field and underlying patterns for development. The objective of this research is to search for novel PAX6 target genes with the long-term goals of identifying genetic pathways for eye development.
The aims are (1) isolation of PAX6-binding DNA fragments; (2) characterization of putative downstream target genes of PAX6; (3) the expression pattern of PAX6 target genes in embryo development.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32EY006949-01
Application #
2776499
Study Section
Special Emphasis Panel (ZRG1-MDCN-7 (02))
Project Start
1999-03-29
Project End
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Biochemistry
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030