RCC1 is the nucleotide exchange factor for the small, Ras-like GTPase Ran. It is involved in many cellular processes including spindle assembly and spindle checkpoint regulation, that when misregulated can lead to cellular transformation and carcinogenesis. Determining how RCC1 is regulated will more clearly define how spindle assembly and checkpoint regulation are controlled and further the development of anticancer therapeutics targeted against these processes. A novel post-translational modification of RCC1, N-terminal serine methylation, has recently been identified in the Macara lab, and this proposal will examine its role in the regulation of RCC1 function.
Specific aim #1 will determine which aspects of RCC1 function N-terminal serine methylation affects and how it regulates these functions.
Specific aim #2 will identify the methyltransferase responsible for the N-terminal serine methylation of RCC1. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM078862-02
Application #
7278264
Study Section
Special Emphasis Panel (ZRG1-F05-J (20))
Program Officer
Haynes, Susan R
Project Start
2006-09-01
Project End
2008-12-10
Budget Start
2007-10-11
Budget End
2008-10-10
Support Year
2
Fiscal Year
2007
Total Cost
$48,796
Indirect Cost
Name
University of Virginia
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904