Abstract

The proposed research will examine gender development in adult intersexual patients. Gender development will be assessed through the use of questionnaires and psychological interviews. Information from these questionnaires and interviews will be analyzed in concert with extent of early androgen exposure, endocrine treatment outcome of the intersexual patients. Lastly, parents of intersexual patients will be questioned concerning the medical decisions they made relating to their child's treatment. Participants will be selected from patients treated for congenital adrenal hyperplasia (CAH) or 46,XY pseudohermaphroditism in the Pediatric Endocrine Clinical at John Hopkins Hospital from 1943 to 1998. This group of intersex patients is one of the largest identified groups available in the United States, and many of these individuals have already been located for previous investigation conducted by Dr. Migeon. This research will broaden our understanding of gender development among intersexual patients while controlling for etiology and treatment (both endocrine and surgical), and may provide useful information regarding the current dispute over appropriate guidelines for medical treatment of intersexual children.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32HD008544-01
Application #
2863486
Study Section
Reproductive Biology Study Section (REB)
Program Officer
Freund, Lisa S
Project Start
1999-03-01
Project End
Budget Start
1999-03-01
Budget End
2000-02-29
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Malouf, Matthew A; Migeon, Claude J; Carson, Kathryn A et al. (2006) Cognitive outcome in adult women affected by congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Horm Res 65:142-50
King, Jeremy A; Wisniewski, Amy B; Bankowski, Brandon J et al. (2006) Long-term corticosteroid replacement and bone mineral density in adult women with classical congenital adrenal hyperplasia. J Clin Endocrinol Metab 91:865-9
Wisniewski, Amy B; Migeon, Claude J; Malouf, Matthew A et al. (2004) Psychosexual outcome in women affected by congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Urol 171:2497-501
Meyer-Bahlburg, H F L; Migeon, C J; Berkovitz, G D et al. (2004) Attitudes of adult 46, XY intersex persons to clinical management policies. J Urol 171:1615-9; discussion 1619
Wisniewski, Amy B; Klein, Sabra L; Lakshmanan, Yegappen et al. (2003) Exposure to genistein during gestation and lactation demasculinizes the reproductive system in rats. J Urol 169:1582-6
Migeon, Claude J; Wisniewski, Amy B; Brown, Terry R et al. (2002) 46,XY intersex individuals: phenotypic and etiologic classification, knowledge of condition, and satisfaction with knowledge in adulthood. Pediatrics 110:e32
Wisniewski, Amy B; Migeon, Claude J (2002) Gender identity/role differentiation in adolescents affected by syndromes of abnormal sex differentiation. Adolesc Med 13:119-28, vii
Wisniewski, Amy B; Migeon, Claude J (2002) Long-term perspectives for 46,XY patients affected by complete androgen insensitivity syndrome or congenital micropenis. Semin Reprod Med 20:297-304
Migeon, Claude J; Wisniewski, Amy B; Gearhart, John P et al. (2002) Ambiguous genitalia with perineoscrotal hypospadias in 46,XY individuals: long-term medical, surgical, and psychosexual outcome. Pediatrics 110:e31
Migeon, C J; Wisniewski, A B (2001) Congenital adrenal hyperplasia owing to 21-hydroxylase deficiency. Growth, development, and therapeutic considerations. Endocrinol Metab Clin North Am 30:193-206

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