This study will investigate the physiological properties of descending inputs to a primary sensory neuropil and the plasticity within this structure that highlights behaviorally significant sensory inputs. The proposed research will be performed in the electrosensory lateral line lobe (ELL) of mormyrid electric fish, a cerebellum-like structure in the medulla. The ELL acts as an adaptive filter in which predictable electrosensory inputs, such as those which are self-generated, are removed from the electrosensory processing stream. The probable mechanism is that of plasticity in the effects of predictive signals conveyed by parallel fibers.
Specific Aim 1 will determine the activity of ELL parallel fibers by recording from the granule cells that give rise to them. Responsiveness of these cells to naturally occurring predictive signals, such as motor commands and proprioceptive signals, will be tested.
Specific Aim 2 will examine the responses of ELL cells to these naturally-occurring predictive signals conveyed by parallel fibers, with a focus on plastic change following a period of association with peripheral electrosensory stimuli. The results of the project will be relevant to the general issues of descending control of sensory processing, storage of sensory information, and cerebellar function.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32MH064355-02
Application #
6529360
Study Section
Integrative, Functional and Cognitive Neuroscience 8 (IFCN)
Program Officer
Curvey, Mary F
Project Start
2002-08-01
Project End
Budget Start
2002-08-01
Budget End
2003-07-31
Support Year
2
Fiscal Year
2002
Total Cost
$44,212
Indirect Cost
Name
Oregon Health and Science University
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Campbell, Holly R; Meek, Johannes; Zhang, Jianmei et al. (2007) Anatomy of the posterior caudal lobe of the cerebellum and the eminentia granularis posterior in a mormyrid fish. J Comp Neurol 502:714-35
Han, Victor Z; Meek, Johannes; Campbell, Holly R et al. (2006) Cell morphology and circuitry in the central lobes of the mormyrid cerebellum. J Comp Neurol 497:309-25