RCMI - CENTER FOR ENVIRONMENTAL HEALTH (CEH) The long-term objective of the CEH is to provide a scientific infrastructure to support research that addresses important environmental and public health issues of concern to vulnerable and underserved communities. To accomplish this objective, we have made the overarching goal of this RCMI application the development of a more comprehensive biomedical research infrastructure to strengthen the capacity to conduct environmental health and health disparities research at Jackson State University (JSU). Toward that end, we propose the following specific aims: (1) To increase the overall research productivity of faculty in the area of environmental health as measured by the number of publications, patents and presentations, and the number and grants submitted and funded by NIH and/or other agencies. We propose to address this aim through implementation of relevant career development activities, including mentoring, scientific advising, faculty portfolio development, granstmanship and scientific writing workshops, biomedical seminars and conferences participation, adequate release time for biomedical research, and timely assessment of progress;(2) To further enhance the environment for conducting cutting-edge environmental health and health disparities research. To achieve this aim we propose to: a) recruit a senior investigator to lead the scientific aspects of the RCMI Program and mentor junior faculty;b) develop multi-user core facilities, providing access to major instrumentation;c) provide training on the use of specialized equipment;d) implement standard operating procedures and policies;and e) monitor facilities utilization and core productivity;(3) To foster opportunities for T1 and T2 translational research. We propose to facilitate expansion of CEH activities in support of intra- and inter-institutional biomedical research collaborations through formal interactions with JSU School of Health Science (SHS), and utilization of the RCMI Translational Research Network (RTRN). To achieve this aim, we propose to: a) provide a joint appointment (between the CSET and the SHS) to the senior investigator who will be hired, b) develop a framework for submission of supplemental pilot projects from the SHS, and c) integrate CEH activities into the RTRN by fully utilizing the RTRN-Data Technology Coordinating Center as a platform to increase tights with other RCMI centers, as well as other institutions of higher learning and national laboratories;and (4) To increase the number of investigators conducting research important in addressing environmental health and health disparities issues. We propose to support four pilot projects by junior investigators who will be teamed with mentors and advisors to assist them with the technical and scientific aspects of their projects, as well as to oversee their career development. As these faculty graduate from the program by gaining external funding, other faculty will be added based on the External Advisory Committee recommendations. Hence, the CEH proposes to develop and implement a new plan that takes advantage of the NIH-NCRR support to modernize its biomedical research infrastructure, and to establish a strong foundation for capacity building that would increase the competitiveness of JSU into mainstream environmental health and health disparities programs funded by the NIH. Additional support is critical for the effective implementation of important CEH activities, as the University embarks into pre-eminence in biomedical research and education.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Research Centers in Minority Institutions Award (G12)
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Special Emphasis Panel (ZRR1-RI-1 (01))
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Sayre, Michael
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Jackson State University
Schools of Arts and Sciences
United States
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Sanders, Talia; Liu, Yi-Ming; Tchounwou, Paul B (2015) Cytotoxic, genotoxic, and neurotoxic effects of Mg, Pb, and Fe on pheochromocytoma (PC-12) cells. Environ Toxicol 30:1445-58
Udensi, Udensi K; Tackett, Alan J; Byrum, Stephanie et al. (2014) Proteomics-Based Identification of Differentially Abundant Proteins from Human Keratinocytes Exposed to Arsenic Trioxide. J Proteomics Bioinform 7:166-178
Graham, Barbara; Stevens, Jacqueline; Wells, Phatia et al. (2014) Enhancement of arsenic trioxide-mediated changes in human induced pluripotent stem cells (IPS). Int J Environ Res Public Health 11:7524-36
Ondera, Thomas J; Hamme 2nd, Ashton T (2014) Gold Nanopopcorn Attached Single-Walled Carbon Nanotube Hybrid for Rapid Detection and Killing of Bacteria. J Mater Chem B Mater Biol Med 2:7534-7543
Tchounwou, Christine K; Yedjou, Clement G; Farah, Ibrahim et al. (2014) D-Glucose-Induced Cytotoxic, Genotoxic, and Apoptotic Effects on Human Breast Adenocarcinoma (MCF-7) Cells. J Cancer Sci Ther 6:156-160
Tchounwou, Paul B (2014) Ninth international symposium on recent advances in environmental health research. Int J Environ Res Public Health 11:1001-4
Gorai, Amit K; Tuluri, Francis; Tchounwou, Paul B (2014) A GIS based approach for assessing the association between air pollution and asthma in New York State, USA. Int J Environ Res Public Health 11:4845-69
Kethireddy, Swatantra R; Tchounwou, Paul B; Ahmad, Hafiz A et al. (2014) Geospatial interpolation and mapping of tropospheric ozone pollution using geostatistics. Int J Environ Res Public Health 11:983-1000
Sims, Jennifer Nicole; Graham, Barbara; Pacurari, Maricica et al. (2014) Di-ethylhexylphthalate (DEHP) modulates cell invasion, migration and anchorage independent growth through targeting S100P in LN-229 glioblastoma cells. Int J Environ Res Public Health 11:5006-19
Pacurari, Maricica; Kafoury, Ramzi; Tchounwou, Paul B et al. (2014) The Renin-Angiotensin-aldosterone system in vascular inflammation and remodeling. Int J Inflam 2014:689360

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