In the past decade, Xavier University of Louisiana has embarked on an ambitious, strategic initiative to enhance its research competitiveness in biomedical fields. Our long term goal is to, in the next 5 to 7 years, be seen nationally not only for our eminence in graduating African American science, pre-med and pharmacy students, but also for national prominence in cancer research. Since 2002, in spite of the destruction rendered by Katrina, Xavier has made significant advances toward achieving this goal through the establishment of both the Center for Minority Health Disparities, launched in 2002, and through membership in the Louisiana Cancer Research Consortium. Xavier researchers have received significant external funding for cancer research from the National Institutes of Health, Department of Defense, National Cancer Institute, and Louisiana Board of Regents, among others. To determine what next steps needed to be taken to build on the above-described progress and take Xavier """"""""to the next level,"""""""" a comprehensive RCMI planning process was carried out through faculty and staff surveys, focus groups, and forums, with the assistance of a variety of external advisors. As a result, barriers to competitiveness and strategies to overcoming them were identified in such areas as recruiting and retaining research competitive faculty, infrastructural support for biomedical research, and lack of centralized core laboratories with supporting staff. To address these barriers, this proposal requests funding to assist Xavier in: (1) increasing the number and quality of Cancer researchers and providing them with start-up packages, release time, and mentoring opportunities;2) enhancing the competitiveness of existing research faculty and programs by providing seed funding for developmental projects, enhanced professional development opportunities and increased access to postdoctoral associates and research staff;(3) developing three research instrumentation cores;(4) offering enhanced administrative services to assure research support activities meet faculty needs, and (5) supporting selected pilot projects that will assist investigators who are at the """"""""cusp"""""""" of becoming fully competitive.

Public Health Relevance

Nationally, and particularly in Louisiana, there are significant disparities between Caucasians and African Americans with regard to Cancer incidence and mortality. African Americans have the highest mortality rate of any racial and ethnic group for most major cancers, making it a major health and human concern.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Research Centers in Minority Institutions Award (G12)
Project #
8G12MD007595-04
Application #
8309874
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Mcclure, Shelia A
Project Start
2009-09-24
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
4
Fiscal Year
2012
Total Cost
$1,773,712
Indirect Cost
$488,792
Name
Xavier University of Louisiana
Department
Type
Other Domestic Higher Education
DUNS #
020857876
City
New Orleans
State
LA
Country
United States
Zip Code
70125
Zhang, Xiaojie; Wang, Rubing; Perez, German Ruiz et al. (2016) Design, synthesis, and biological evaluation of 1,9-diheteroarylnona-1,3,6,8-tetraen-5-ones as a new class of anti-prostate cancer agents. Bioorg Med Chem 24:4692-700
Schroeder, Richard L; Tram, Phan; Liu, Jiawang et al. (2016) Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome P450 inhibition: a patent evaluation WO2015048311 (A1). Expert Opin Ther Pat 26:139-47
Vanden Eynde, Jean J; Mayence, Annie; Mottamal, Madhusoodanan et al. (2016) Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents. Pharmaceuticals (Basel) 9:
Crespo-Salgado, Janice; Vehaskari, V Matti; Stewart, Tyrus et al. (2016) Intestinal microbiota in pediatric patients with end stage renal disease: a Midwest Pediatric Nephrology Consortium study. Microbiome 4:50
Carriere, Patrick P; Llopis, Shawn D; Naiki, Anna C et al. (2016) Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1. Int J Environ Res Public Health 13:ijerph13010010
Vue, Bao; Zhang, Sheng; Zhang, Xiaojie et al. (2016) Silibinin derivatives as anti-prostate cancer agents: Synthesis and cell-based evaluations. Eur J Med Chem 109:36-46
Zhang, Sheng; Vue, Bao; Huang, Michael et al. (2016) 3-O-Alkyl-2,3-dehydrosilibinins: Two synthetic approaches and in vitro effects toward prostate cancer cells. Bioorg Med Chem Lett 26:3226-31
Li, Xiang; Chen, Guanglin; Zhang, Xiaojie et al. (2016) A new class of flavonol-based anti-prostate cancer agents: Design, synthesis, and evaluation in cell models. Bioorg Med Chem Lett 26:4241-5
Schexnayder, Chandler; Stratford, Robert E (2016) Genistein and Glyceollin Effects on ABCC2 (MRP2) and ABCG2 (BCRP) in Caco-2 Cells. Int J Environ Res Public Health 13:ijerph13010017
Mei, Suyu; Zhang, Kun (2016) Multi-label â„“2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks. Sci Rep 6:36453

Showing the most recent 10 out of 104 publications