This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The TNC Microenvironment in the Development of Systemic Lupus Erythematosus. Thymic Nurse Cells (TNCs) have a major role in MHC restriction and the removal of apoptotic thymocytes. TNCs are severely depleted with disease onset and progression in systemic lupus erythematosus (SLE). The major goal of this study is to determine if the replacement of TNCs in the thymus of lupus mice will reduce or eliminate disease symptoms. In these studies thymic nurse cells were found to express the cytokeratins five and eight (K5 and K8) as well as the transcription factor 63 (Trp-63). The expression of Trp-63 is a characteristic of epithelial cell progenitors. This suggests that TNCs may have the potential to repopulate epithelial-free zones characteristic of the thymi of lupus-prone mice.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR003059-22
Application #
8357145
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Project Start
2011-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
22
Fiscal Year
2011
Total Cost
$100,146
Indirect Cost
Name
Tuskegee University
Department
Type
Schools of Allied Health Profes
DUNS #
128214178
City
Tuskegee
State
AL
Country
United States
Zip Code
36088
Mukherjee, Angana; Hollern, Daniel P; Williams, Oluwasina G et al. (2018) A Review of FOXI3 Regulation of Development and Possible Roles in Cancer Progression and Metastasis. Front Cell Dev Biol 6:69
Yates, Clayton; Long, Mark D; Campbell, Moray J et al. (2017) miRNAs as drivers of TMPRSS2-ERG negative prostate tumors in African American men. Front Biosci (Landmark Ed) 22:212-229
Chowdhury, Rupak; David, Nganwa; Bogale, Asseged et al. (2016) Assessing the Key Attributes of Low Utilization of Mammography Screening and Breast-self Exam among African-American Women. J Cancer 7:532-7
Jones, Jacqueline; Mukherjee, Angana; Karanam, Balasubramanyam et al. (2016) African Americans with pancreatic ductal adenocarcinoma exhibit gender differences in Kaiso expression. Cancer Lett 380:513-22
Wang, Honghe; Liu, Wei; Black, ShaNekkia et al. (2016) Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression. Oncotarget 7:5677-89
Reams, R Renee; Jones-Triche, Jacqueline; Chan, Owen T M et al. (2015) Immunohistological analysis of ABCD3 expression in Caucasian and African American prostate tumors. Biomed Res Int 2015:132981
Arora, Ritu; Schmitt, David; Karanam, Balasubramanyam et al. (2015) Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers. Oncotarget 6:662-78
Jones, Jacqueline; Wang, Honghe; Karanam, Balasubramanyam et al. (2014) Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas. Clin Exp Metastasis 31:497-510
Okumu, Lilian A; Braden, Tim D; Vail, Krystal et al. (2014) Low androgen induced penile maldevelopment involves altered gene expression of biomarkers of smooth muscle differentiation and a key enzyme regulating cavernous smooth muscle cell tone. J Urol 192:267-73
Theodore, Shaniece C; Davis, Melissa; Zhao, Fu et al. (2014) MicroRNA profiling of novel African American and Caucasian Prostate Cancer cell lines reveals a reciprocal regulatory relationship of miR-152 and DNA methyltranferase 1. Oncotarget 5:3512-25

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