This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The work of Area III Neurobiology is focused on the neural mechanisms underlying development, with special concern for how the interactions among cell types in the developing organism change the function and fate of particular cells, generally via humoral factors. Of the six members of area III, five were hired through the RCMI. All of the researchers are funded by external grants, including five of the members with R01 grants. Jay Edelman studies how cognition and sensory signals interact to create saccadic eye movement commands in humans. Jonathan Levitt uses neuroanatomical and neurophysiological methods to study the properties of single cells in visual areas of the cerebral cortex and the rules governing connections among the different regions. He is interested in how cells'responsiveness and selectivity to visual stimuli is modified by stimuli that do not by themselves evoke responses. Christine Li uses genetic methods to understand the function and regulation of a family of neuropeptide genes in the nematode Caenorhaditis elegans. She also studies a C. elegans protein related to the human amyloid precursor protein, a cleavage product of which is prevalent in the brains of Alzheimer's patients. Ofer Tchernichovski studies developmental learning in birds. On a behavioral level his lab examines how sleep affects vocal development, on a systems level his lab studies developmental changes in brain responses to auditory stimuli, and on a molecular level, his lab studies how patterns of immediate early gene expression correlate with vocal learning. Tadmiri Venkatesh studies the molecular genetic mechanisms that regulate cell cycle exit during nervous system development in Drosophila and the role of cAMP mediated signaling pathway in neuronal development and plasticity. He has recently initiated molecular genetic studies on the role of signaling pathways during the development of the mouse retina after creating Kremen-1 knockout mice while on sabatical at Stanford. Josh Wallman studies how the visual system regulates the growth of the eye. When this regulation fails eyes become nearsighted or farsighted. He imposes defocus on the developing eye by having chicks wear spectacle lenses that make them myopic or hyperopic and studies how the growth of the eye compensates, both phenomenologically and biochemically. He also studies eye movements in humans, both with respect to plasticity and the effects of attention. Area III has also continued a Neurobiology Seminar series. Our intention is to have, in addition to the seminar, a structured discussion on specific topics, prepared by having the faculty and students read papers in advance. These seminars have promoted lively conversation within the group and have led to collaborative projects with several of the visiting scientists.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
2G12RR003060-26A1
Application #
8357147
Study Section
Special Emphasis Panel (ZRR1-RI-B (02))
Project Start
2011-09-21
Project End
2012-07-31
Budget Start
2011-09-21
Budget End
2012-07-31
Support Year
26
Fiscal Year
2011
Total Cost
$342,750
Indirect Cost
Name
City College of New York
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
603503991
City
New York
State
NY
Country
United States
Zip Code
10031
Akula, Hari K; Kokatla, Hariprasad; Andrei, Graciela et al. (2017) Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products. Org Biomol Chem 15:1130-1139
Shi, Lingyan; Lu, Luyao; Harvey, George et al. (2017) Label-Free Fluorescence Spectroscopy for Detecting Key Biomolecules in Brain Tissue from a Mouse Model of Alzheimer's Disease. Sci Rep 7:2599
Huang, Wenlin; Serra, Olga; Dastmalchi, Keyvan et al. (2017) Comprehensive MS and Solid-State NMR Metabolomic Profiling Reveals Molecular Variations in Native Periderms from Four Solanum tuberosum Potato Cultivars. J Agric Food Chem 65:2258-2274
Patel, Joy; Lama, Lodoe; Hoffmann, Niklas A et al. (2017) RNA polymerase III initiation on coligo DNA templates containing loops of variable sequence, size and nucleotide chemistry. Gene 612:49-54
Orlova, Natalia; Gerding, Matthew; Ivashkiv, Olha et al. (2017) The replication initiator of the cholera pathogen's second chromosome shows structural similarity to plasmid initiators. Nucleic Acids Res 45:3724-3737
Lee, Kwangwoon; Alphonse, S├ębastien; Piserchio, Andrea et al. (2016) Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin. Structure 24:1441-51
Saribudak, Aydin; Kucharavy, Herman; Hubbard, Karen et al. (2016) Spatial Heterogeneity Analysis in Evaluation of Cell Viability and Apoptosis for Colorectal Cancer Cells. IEEE J Transl Eng Health Med 4:4300209
Sengupta, Ananya; Upadhyay, Ghanshyam; Sen, Sayani et al. (2016) Reciprocal regulation of alternative lineages by Rgs18 and its transcriptional repressor Gfi1b. J Cell Sci 129:145-54
Lama, Lodoe; Ryan, Kevin (2016) Adenylylation of small RNA sequencing adapters using the TS2126 RNA ligase I. RNA 22:155-61
Wang, Naidong; Zhan, Yang; Wang, Aibing et al. (2016) In silico analysis of surface structure variation of PCV2 capsid resulting from loop mutations of its capsid protein (Cap). J Gen Virol 97:3331-3344

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