Biomedical research at Clark Atlanta University (CAU) has been supported by the National Center for Research Resources (NCRR)/National Institutes of Health (NIH)-sponsored Research Center in Minority Institutions (RCMI) program since 1985. The RCMI program at CAU over the last 20 years has been vital for the development of infrastructure for biomedical research by providing state-of-the-art equipment, recruitment of faculty and resources for individual researchers. The Center for Cancer Research and Therapeutic Development (CCRTD) was created in 1999 with support from the RCMI program. CCRTD faculty belongs to the Departments of Biology, Chemistry and School of Education with research interests in cancer biology, drug discovery and behavioral aspects of cancer. During the current funding period, CCRTD decided to focus on the development of a nationally-recognized research program in prostate cancer. As a part of this initiative, CAU recruited three new faculty members with research programs focused on prostate cancer research and education. The well-defined and focused activities at CCRTD have resulted in increased productivity and the stature of biomedical research at CAU. During the next funding period, we will continue to expand and enhance our research activities to achieve the goals of building a world class Center dedicated to research in prostate cancer and its impact in the African American community. The proposed specific goals are: 1) to develop and expand current research core facilities vital for carrying out research on the cellular and molecular biology of prostate cancer and 2) to recruit additional faculty who will further strengthen CCRTD. To provide additional support to CCRTD investigators, we propose to establish two new core units within CCRTD Research Support Core Facilities: Bioinformatics and Biostatistics Core and Analytical Core. We also propose to recruit three additional faculty members who will be committed to high caliber research in prostate cancer biology and chemistry. Additional faculty is imperative to achieve a critical mass of scientists working in a collaborative and synergistic environment to create a world class center in prostate cancer research at CAU. This will be a unique Center of its kind at an HBCU. Prostate cancer affects the African American community disproportionately. There is an increased incidence/mortality rate for African American men;however the reason for this is unknown. The Center for Cancer Research and Therapeutic Development is committed to focus on the impact of this health disparity within the African American community.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR003062-25
Application #
8129692
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Cooper, Leslie
Project Start
1997-06-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
25
Fiscal Year
2011
Total Cost
$1,477,867
Indirect Cost
Name
Clark Atlanta University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
065325177
City
Atlanta
State
GA
Country
United States
Zip Code
30314
Joshi, Jugal Bharat; Patel, Divya; Morton, Derrick J et al. (2017) Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52. Mol Oncol 11:337-357
Morton, Derrick J; Patel, Divya; Joshi, Jugal et al. (2017) ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation. Oncotarget 8:2536-2549
Komaragiri, Shravan Kumar; Bostanthirige, Dhanushka H; Morton, Derrick J et al. (2016) ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells. Biochem Biophys Res Commun 478:60-66
Wilder, Catera L; Walton, Charlene; Watson, Valencia et al. (2016) Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells. Int J Biochem Cell Biol 79:199-208
Brown, Shanora G; Knowell, Ashley E; Hunt, Aisha et al. (2015) Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis. Prostate 75:266-79
Muniyan, Sakthivel; Chou, Yu-Wei; Tsai, Te-Jung et al. (2015) p66Shc longevity protein regulates the proliferation of human ovarian cancer cells. Mol Carcinog 54:618-31
Goodson 3rd, William H; Lowe, Leroy; Carpenter, David O et al. (2015) Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis 36 Suppl 1:S254-96
Burton, Liza J; Smith, Basil A; Smith, Bethany N et al. (2015) Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells. Carcinogenesis 36:1019-27
Chinaranagari, Swathi; Sharma, Pankaj; Bowen, Nathan J et al. (2015) Prostate cancer epigenome. Methods Mol Biol 1238:125-40
Mandal, S; Abebe, F; Chaudhary, J (2014) -174G/C polymorphism in the interleukin-6 promoter is differently associated with prostate cancer incidence depending on race. Genet Mol Res 13:139-51

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