Despite a greater accumulation of risk factors for at-risk drinking and alcohol use disorders, national epidemiological surveys consistently report that Blacks and Hispanics in the United States (US) have an comparable or lower prevalence of binge drinking and alcohol disorders compared to non-Hispanic Whites. However, mortality data indicate that they have higher rates of alcohol-attributable motor vehicle crash fatality (MVCF). These seemingly divergent patterns indicate an epidemiologic paradox, the consequences of which are important for public health: MVCF is a leading cause of death among young adults, Blacks and Hispanics experience substantial inequities in MVCF compared to non-Hispanic Whites, and approximately 30% of all MVCFs are alcohol-related. In the present application for a Mentored Research Scientist Development Award (K01), I propose to develop expertise in four areas that will allow me to develop a line of research into the racial/ethnic paradox in alcohol-related health: 1) Built environment effects on alcohol-related health; 2) Conceptualization and measurement of cultural and social norms regarding alcohol use; 3) Analysis of repeated measures data; and 4) Field methods in epidemiologic data collection. I will use the skills obtained in these training areas to begin to fill outstanding gaps in our understanding of racial/ethnic differences in alcohol- related health with three research projects, for which the K01 will allow me protected research time that would otherwise not be possible as a new assistant professor. First, I will probe the validity of the racial/ethnic paradox itself. I ill explore whether lower rates of problem drinking among racial/ethnic minorities are limited to adolescents and young adults, and whether rates of problem drinking among older adults are higher among Blacks and Hispanics compared to non-Hispanic Whites. This work will utilize a national longitudinal dataset and incorporate information on trajectories within Blacks and Latino subgroups, which have never been characterized. Second, I will determine if alcohol-related social norms mediate overall differences in alcohol use and MVC risk, adding to our knowledge of how the paradox arises. I will use data from the New York Social Environment Survey, an epidemiologic study in New York City with rich racial and ethnic diversity and one of the only community-based samples to measure alcohol norms. Third, I will test a potential mechanism to explain the racial/ethnic paradox: that Black and Hispanic individuals experience more alcohol-attributable MVCF because the built environment in which they consume alcohol is more dangerous (e.g., worse road conditions). To test this hypothesis I propose a novel study linking records from the Fatality Analysis Reporting System on a national level with census and land usage information. In addition to these research aims, my K01 award period will focus on preparation of an R01 grant proposal to collect original data on racial/ethnic differences in alcohol-related health that builds on and extends the research proposed here. These projects are feasible only if I have protected time for new training and research, which K01 funding will provide.

Public Health Relevance

The present proposal examines a long-standing but little investigated 'paradox' in alcohol epidemiology: epidemiological surveys consistently report that Black and Latino populations have comparable or lower prevalence of alcohol disorders compared to non-Hispanic Whites, but bear a disproportionate amount of harm from alcohol in the form of injury and illness. The training and research proposed here will form the background of a new line of inquiry to examine how racial/ethnic differences are shaped over the life course, and how the built environment as well as cultural/social norms shape alcohol-related risk. These inquires have substantial promise for public health; accurate empirical data regarding the emergence of racial/ethnic differences across the life course and explanations for the epidemiologic 'paradox' in alcohol-related health are crucial to better understanding the role of minority status in the development and persistence of alcohol disorders as well as alcohol-related motor-vehicle crash risk.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Scientist Development Award - Research & Training (K01)
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Neuroscience Review Subcommittee (AA)
Program Officer
Godette, Dionne
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Columbia University (N.Y.)
Public Health & Prev Medicine
Schools of Public Health
New York
United States
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Santaella-Tenorio, Julian; Mauro, Christine M; Wall, Melanie M et al. (2017) US Traffic Fatalities, 1985-2014, and Their Relationship to Medical Marijuana Laws. Am J Public Health 107:336-342
Keyes, Katherine M; Wall, Melanie; Feng, Tianshu et al. (2017) Race/ethnicity and marijuana use in the United States: Diminishing differences in the prevalence of use, 2006-2015. Drug Alcohol Depend 179:379-386
Keyes, Katherine M; Galea, Sandro (2017) Re: Some Thoughts on Consequential Epidemiology and Causal Architecture. Epidemiology 28:e31-e32
Keyes, Katherine M; Platt, Jonathan; Kaufman, Alan S et al. (2017) Association of Fluid Intelligence and Psychiatric Disorders in a Population-Representative Sample of US Adolescents. JAMA Psychiatry 74:179-188
Walsh, Kate; McLaughlin, Katie A; Hamilton, Ava et al. (2017) Trauma exposure, incident psychiatric disorders, and disorder transitions in a longitudinal population representative sample. J Psychiatr Res 92:212-218
Chapman, Cath; Slade, Tim; Swift, Wendy et al. (2017) Evidence for Sex Convergence in Prevalence of Cannabis Use: A Systematic Review and Meta-Regression. J Stud Alcohol Drugs 78:344-352
Cerdá, Magdalena; Wall, Melanie; Feng, Tianshu et al. (2017) Association of State Recreational Marijuana Laws With Adolescent Marijuana Use. JAMA Pediatr 171:142-149
LeWinn, Kaja Z; Sheridan, Margaret A; Keyes, Katherine M et al. (2017) Sample composition alters associations between age and brain structure. Nat Commun 8:874
Susser, Ezra; Keyes, Katherine M (2017) Prenatal Nutritional Deficiency and Psychosis: Where Do We Go From Here? JAMA Psychiatry 74:349-350
Cerdá, Magdalena; Gaidus, Andrew; Keyes, Katherine M et al. (2017) Prescription opioid poisoning across urban and rural areas: identifying vulnerable groups and geographic areas. Addiction 112:103-112

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