The overall objective of this K01 proposal is to enable Dr. Friedman to develop the skills and expertise necessary for independent integrative research on psychosocial well-being and health in aging adults. Inflammation typically increases with age and has been linked to a range of age-related disorders, including heart disease and diabetes. The key hypothesis of the proposed research is that positive psychosocial functioning will predict lower levels of blood-borne inflammatory proteins in older adults and will moderate the negative impact of chronic life adversity. In order to conduct this work, Dr. Friedman seeks additional training in geriatric health, epidemiology, and analytical methodology. The proposed Training Plan includes both formal coursework and intensive mentorship focused on these topics. These didactic activities will complement Dr. Friedman's background in psychoneuroimmunology and enable him (a) to examine multiple dimensions of human functioning using longitudinal psychosocial data from the Survey of Midlife in the United States (MIDUS) and (b) to link these data to newly assessed neurobiological measures, including inflammatory factors. The Research Plan will utilize the new concepts and techniques learned to test four key hypotheses: (1) positive psychosocial functioning will predict low levels of inflammatory proteins and will moderate the associations of inflammation with low socioeconomic status and chronic stress;(2) neuroendocrine function (diurnal cortisol slopes;cortisol levels under resting conditions and in response to laboratory stressors) will mediate the association of psychosocial functioning and inflammatory proteins;(3) neural indices of emotion regulation (EEG asymmetry) will predict low levels of inflammatory proteins;and (4) integrative analyses of psychosocial, sociodemographic, neuroendocrine, and neural circuitry factors will identify pathways through which these multiple domains interact (using recursive partitioning) to predict high or low levels of inflammatory proteins. This combination of didactic and research experiences will equip Dr. Friedman with the knowledge and skills necessary for a successful career transition to independent research focused on multi-domain human experience and health. The research is also expected to generate new information about links between positive psychosocial functioning and inflammatory processes that will aid in the identification and targeting of effective interventions to improve health and well-being in later life.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AG029381-05
Application #
8097476
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Nielsen, Lisbeth
Project Start
2007-08-15
Project End
2012-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
5
Fiscal Year
2011
Total Cost
$135,000
Indirect Cost
Name
University of Wisconsin Madison
Department
Other Health Professions
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Hale, Lauren; Hill, Terrence D; Friedman, Elliot et al. (2013) Perceived neighborhood quality, sleep quality, and health status: evidence from the Survey of the Health of Wisconsin. Soc Sci Med 79:16-22
Herd, Pamela; Karraker, Amelia; Friedman, Elliot (2012) The social patterns of a biological risk factor for disease: race, gender, socioeconomic position, and C-reactive protein. J Gerontol B Psychol Sci Soc Sci 67:503-13
Ryff, Carol; Friedman, Elliot; Fuller-Rowell, Thomas et al. (2012) Varieties of Resilience in MIDUS. Soc Personal Psychol Compass 6:792-806
Friedman, Elliot M (2011) Sleep quality, social well-being, gender, and inflammation: an integrative analysis in a national sample. Ann N Y Acad Sci 1231:23-34
Greenfield, Emily A; Lee, Chioun; Friedman, Elliot L et al. (2011) Childhood abuse as a risk factor for sleep problems in adulthood: evidence from a U.S. national study. Ann Behav Med 42:245-56
Nieto, F Javier; Peppard, Paul E; Engelman, Corinne D et al. (2010) The Survey of the Health of Wisconsin (SHOW), a novel infrastructure for population health research: rationale and methods. BMC Public Health 10:785
Friedman, Elliot M; Herd, Pamela (2010) Income, education, and inflammation: differential associations in a national probability sample (The MIDUS study). Psychosom Med 72:290-300
Morozink, Jennifer A; Friedman, Elliot M; Coe, Christopher L et al. (2010) Socioeconomic and psychosocial predictors of interleukin-6 in the MIDUS national sample. Health Psychol 29:626-35
Krueger, Patrick M; Friedman, Elliot M (2009) Sleep duration in the United States: a cross-sectional population-based study. Am J Epidemiol 169:1052-63
Friedman, Elliot M; Williams, David R; Singer, Burton H et al. (2009) Chronic discrimination predicts higher circulating levels of E-selectin in a national sample: the MIDUS study. Brain Behav Immun 23:684-92