Dr. Gloria H. Su received her Ph.D. from the University of Chicago. During which, she acquired expertise in the development and analysis of knock-out mice in the laboratory of Dr. M. Celeste Simon. In her postdoctoral training in the molecular genetics laboratory of Dr. Scott E. Kern at The Johns Hopkins University, she identified several tumor suppressor genes important to human pancreatic and biliary adenocarcinomas. She joined the faculty at The Johns Hopkins University in July 2000 in the Department of Pathology, and has since combined her two areas of expertise to focus on the development of mouse models for human pancreatic cancer. Most patients with pancreatic cancer are diagnosed at an advanced stage and the current available treatments are not effective in prolonging the patients' survival. New approaches for early diagnoses and treatment could be extensively studied in animal models, if one were available. The continued discoveries of tumor suppressor genes important in pancreatic cancer have now rendered it possible to construct an animal model to further our understanding of pancreatic tumorigenesis. Creating mouse models that mirror human pancreatic tumorigenesis using knock-out and transgenic techniques is one of Dr. Su's major goals. Here she proposes to study the in vivo impact of a tumor-suppressor gene, DPC4 (SMAD4/MADH4), important for human pancreatic cancer, using conditional knock-out mice and a transgenic mouse line carrying DPC4-specific reporter gene. Dr. Su's position at The Johns Hopkins University will provide her access to important resources such as the Transgenic Mouse Core Laboratory, and the intellectual support of a large group of scientists and clinicians dedicated to curing pancreatic cancer. Among them are her sponsors, Drs. Scott E. Kern and Steven D. Leach, who are internationally recognized researchers in the field of pancreatic cancer. From her sponsors, she will continue to gain valuable lessons on the human genetics, pathology of pancreatic cancer, and murine pancreatic development. The clinical backgrounds and focus of her mentors will also assist Dr. Su in framing her research effort so that they remain directly relevant to human pancreatic cancer. With the enormous support of her mentors, colleagues, and the Department of Pathology, Dr. Su will be able to conduct her research in the richest intellectual and resourceful environment possible for academic and research career development.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
7K01CA095434-02
Application #
6667362
Study Section
Subcommittee G - Education (NCI)
Program Officer
Eckstein, David J
Project Start
2002-09-27
Project End
2007-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
2
Fiscal Year
2003
Total Cost
$146,837
Indirect Cost
Name
Columbia University (N.Y.)
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Qiu, Wanglong; Tang, Sophia M; Lee, Sohyae et al. (2016) Loss of Activin Receptor Type 1B Accelerates Development of Intraductal Papillary Mucinous Neoplasms in Mice With Activated KRAS. Gastroenterology 150:218-228.e12
Garcia-Carracedo, Dario; Yu, Chih-Chieh; Akhavan, Nathan et al. (2015) Smad4 loss synergizes with TGF? overexpression in promoting pancreatic metaplasia, PanIN development, and fibrosis. PLoS One 10:e0120851
Qiu, Wanglong; Sahin, Fikret; Iacobuzio-Donahue, Christine A et al. (2011) Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo. Oncotarget 2:862-73
Qiu, Wanglong; Li, Xiaojun; Tang, Hongyan et al. (2011) Conditional activin receptor type 1B (Acvr1b) knockout mice reveal hair loss abnormality. J Invest Dermatol 131:1067-76
Lee, Dong Jin; Schonleben, Frank; Banuchi, Victoria E et al. (2010) Multiple tumor-suppressor genes on chromosome 3p contribute to head and neck squamous cell carcinoma tumorigenesis. Cancer Biol Ther 10:689-93
Qiu, Wanglong; Tong, Guo-Xia; Manolidis, Spiros et al. (2008) Novel mutant-enriched sequencing identified high frequency of PIK3CA mutations in pharyngeal cancer. Int J Cancer 122:1189-94
Schonleben, Frank; Allendorf, John D; Qiu, Wanglong et al. (2008) Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas. Pancreas 36:168-72
Schonleben, Frank; Qiu, Wanglong; Remotti, Helen E et al. (2008) PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas. Langenbecks Arch Surg 393:289-96
Schonleben, Frank; Qiu, Wanglong; Bruckman, Karl C et al. (2007) BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas. Cancer Lett 249:242-8
Qiu, Wanglong; Schonleben, Frank; Li, Xiaojun et al. (2007) Disruption of transforming growth factor beta-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4. Cancer Lett 245:163-70

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