The purpose of this proposal is to provide Dr. Mrug, the applicant, with new training in substance use research and advanced statistical modeling to develop her career as an independent investigator in the area of adolescent substance use and abuse. The ultimate career goal of the applicant is to develop preventive interventions tailored to specific subgroups of youth. Consistent with this long-term goal, the proposed research program focuses on the role of gender and ethnicity in initiation of substance use in preadolescent and early adolescent populations. Specifically, we seek to 1) describe gender and ethnic differences in preadolescent and early adolescent use of alcohol, tobacco, marijuana, and inhalants;2) examine specific parenting practices as mediators of these gender and ethnic differences;3) identify the impact of neighborhood context on parenting and substance use in preadolescence and early adolescence;and 4) examine whether early initiation of substance use represents higher risk for future substance-related and Functional outcomes in specific gender and ethnic subgroups. This research will provide important insights into the role of gender and ethnicity in early substance use and provide useful information for developing tailored preventive interventions for girls and boys of different ethnicities. The K01 award would provide the applicant with the skills and mentoring necessary to carry out the proposed research and allow her to fully focus on developing the research program. Proposed training activities include a structured 4-year program of individual mentoring, coursework, and supervised research under the direction of senior mentors in the areas of adolescent substance use (Dr. Windle), advanced statistical methods (Dr. Roth), and contextual influences on adolescent risk behavior (Dr. Bolland), as well as additional training in the responsible conduct of research. To accomplish the specific aims of this proposal, Dr. Mrug will conduct secondary data analyses of two data sets (Healthy Passages and Birmingham Youth Violence Study) and collect follow-up data on participants in the Birmingham Youth Violence Study. In addition to publication and conference presentation of empirical findings, Dr. Mrug will write and submit an independent research grant (R01) in later stages of this award.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Scientist Development Award - Research & Training (K01)
Project #
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Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Etz, Kathleen
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University of Alabama Birmingham
Schools of Arts and Sciences
United States
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Mrug, Sylvie; Madan, Anjana; Windle, Michael (2016) Emotional Desensitization to Violence Contributes to Adolescents' Violent Behavior. J Abnorm Child Psychol 44:75-86
Morris, Anjana Madan; Mrug, Sylvie; Windle, Michael (2015) From Family Violence to Dating Violence: Testing a Dual Pathway Model. J Youth Adolesc 44:1819-35
Hill, Danielle; Mrug, Sylvie (2015) School-Level Correlates of Adolescent Tobacco, Alcohol, and Marijuana Use. Subst Use Misuse 50:1518-28
Mrug, Sylvie; Elliott, Marc N; Davies, Susan et al. (2014) Early puberty, negative peer influence, and problem behaviors in adolescent girls. Pediatrics 133:7-14
Reynolds, Nina; Mrug, Sylvie; Britton, LaCrecia et al. (2014) Spiritual coping predicts 5-year health outcomes in adolescents with cystic fibrosis. J Cyst Fibros 13:593-600
Reynolds, Nina; Mrug, Sylvie; Guion, Kimberly (2013) Spiritual coping and psychosocial adjustment of adolescents with chronic illness: the role of cognitive attributions, age, and disease group. J Adolesc Health 52:559-65
Mrug, Sylvie; McCay, Riley (2013) Parental and peer disapproval of alcohol use and its relationship to adolescent drinking: age, gender, and racial differences. Psychol Addict Behav 27:604-14
Goncy, Elizabeth A; Mrug, Sylvie (2013) Where and when adolescents use tobacco, alcohol, and marijuana: comparisons by age, gender, and race. J Stud Alcohol Drugs 74:288-300
Garner, Annie A; Mrug, Sylvie; Hodgens, Bart et al. (2013) Do symptoms of sluggish cognitive tempo in children with ADHD symptoms represent comorbid internalizing difficulties? J Atten Disord 17:510-8
Mrug, Sylvie; Madan, Anjana; Windle, Michael (2012) Temperament alters susceptibility to negative peer influence in early adolescence. J Abnorm Child Psychol 40:201-9

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