Mentored Research Scientist Award for Tara M. Chaplin, Ph.D. This K01 application seeks support that is essential for my development as an independent interdisciplinary scientist. I have developed an important program of psychosocial research on gender, patterns of emotional response to stress, and the development of depression in adolescence. However, to fully understand the impact of emotional arousal patterns on adolescent psychopathology, I must incorporate biological aspects of emotion and must understand the role of emotion in both internalizing disorders such as depression and externalizing disorders such as substance abuse. Therefore, in this K01 application, I propose to acquire training in three areas: (a) developmental neurobiology models and measures of emotion and psychopathology;(b) substance abuse research;and (c) advanced data analytic techniques for repeated bio-psycho-social data and complex developmental models, including Linear Mixed Effects and Structural Equation Modeling. Training will be provided through intensive mentoring by a team of leading interdisciplinary scientists, and through guided readings, coursework, and attendance at conferences/meetings. I will also complete a research project examining the role of emotional response to stress in the development of substance use and depressive symptoms in 200 adolescents (aged 14-15 years), half of whom are at risk for the development of adjustment problems due to prenatal cocaine exposure. Prenatal cocaine exposure (PCE) is known to specifically impact emotional arousal systems and may also be a risk factor for substance use disorders and depression in adolescence. However, no published studies have followed PCE children into adolescence to test this possibility. The proposed study follows a well-characterized cohort of adolescents who have been studied since their birth. Half of the adolescents were prenatally exposed to cocaine and the other half were not exposed to substances, with both groups from low-income families. Adolescents will participate in a laboratory-based stress task (the Trier Social Stress Test, TSST) with detailed assessments of their emotional responses across bio-psychosocial domains. Adolescent's subjective emotion experience, observed emotion expression, cardiovascular arousal (HR, BP), and HPA-Axis arousal (cortisol levels) will be assessed before, during, and after the TSST. Adolescents will complete 6- and 12-month follow-up assessments of substance use/abuse and depression. Analyses will examine associations between emotional response to the stressor and increases in substance use and depressive symptoms by 12-month follow-up. Understanding possible mechanisms for the initiation and early escalation of substance use disorders and depression will inform the development of interventions for adolescents at risk and the proposed Award will enable me to contribute to this field.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01DA024759-05
Application #
8262703
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Noursi, Samia
Project Start
2008-05-01
Project End
2013-07-30
Budget Start
2012-05-01
Budget End
2013-07-30
Support Year
5
Fiscal Year
2012
Total Cost
$191,204
Indirect Cost
$14,163
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Turpyn, Caitlin C; Chaplin, Tara M (2016) Mindful Parenting and Parents' Emotion Expression: Effects on Adolescent Risk Behaviors. Mindfulness (N Y) 7:246-254
Chaplin, Tara M; Visconti, Kari Jeanne; Molfese, Peter J et al. (2015) Prenatal cocaine exposure differentially affects stress responses in girls and boys: associations with future substance use. Dev Psychopathol 27:163-80
Turpyn, Caitlin C; Chaplin, Tara M; Cook, Emily C et al. (2015) A person-centered approach to adolescent emotion regulation: Associations with psychopathology and parenting. J Exp Child Psychol 136:1-16
Chaplin, Tara M (2015) Gender and Emotion Expression: A Developmental Contextual Perspective. Emot Rev 7:14-21
Chaplin, Tara M; Hansen, Amysue; Simmons, Jessica et al. (2014) Parental-adolescent drug use discussions: physiological responses and associated outcomes. J Adolesc Health 55:730-5
Chaplin, Tara M; Aldao, Amelia (2013) Gender differences in emotion expression in children: a meta-analytic review. Psychol Bull 139:735-65
Chaplin, Tara M; Sinha, Rajita; Simmons, Jessica A et al. (2012) Parent-adolescent conflict interactions and adolescent alcohol use. Addict Behav 37:605-12
Liu, Jie; Chaplin, Tara M; Wang, Fei et al. (2012) Stress reactivity and corticolimbic response to emotional faces in adolescents. J Am Acad Child Adolesc Psychiatry 51:304-12
Cook, Emily C; Chaplin, Tara M; Sinha, Rajita et al. (2012) The stress response and adolescents' adjustment: the impact of child maltreatment. J Youth Adolesc 41:1067-77
Chaplin, Tara M; Casey, James; Sinha, Rajita et al. (2010) Gender differences in caregiver emotion socialization of low-income toddlers. New Dir Child Adolesc Dev 2010:11-27

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