The goal of this Mentored Research Scientist Development Award (K01) is to prepare Dr. Dale Bond to become an independent scientist studying innovative behavioral approaches for the treatment of severe obesity, with specific emphasis on strategies to increase physical activity. Through a combination of didactic and direct mentored training experiences, this training plan will provide him with knowledge and skills in the following areas: severe obesity and bariatric surgical procedures;behavioral treatment of severe obesity, with emphasis on strategies to increase and measure physical activity;and methodology, statistics and the ethics of clinical trials in severe obesity. Dr. Bond will work closely with his mentor, Dr. Rena Wing, and his multidisciplinary team of co-mentors Drs. Harry Sax (surgeon), John Jakicic (exercise physiologist) and Joseph Fava (quantitative psychologist) throughout the course of the award. The resources at The Miriam Hospital/Brown Medical School combined with the mentoring by an expert advisory team will provide Dr. Bond with the ideal environment to achieve his long-term career objectives. The proportion of Americans who are severly [sic] obese or more than 100 pounds overweight is rapidly increasing. This presents a significant public health challenge as severely obese individuals have a higher rate of comorbidities and exact a greater toll on the health care system than less obese persons. For these individuals, bariatric surgery is currently the treatment of choice for producing substantial and long-term weight loss, although outcomes vary. Low physical activity is one behavioral factor that undermines surgical success. However, structured behavioral interventions to increase physical activity in bariatric surgery patients have not been conducted. Thus, the proposed study involves a randomized controlled trial comparing the effects of a behavioral intervention to increase physical activity, a behavioral intervention to decrease sedentary behaviors, and a standard care control group on changes in objectively-measured preoperative and postoperative physical activity among 75 adult bariatric surgery patients with low level of physical activity. The long-term goal of this research is to improve bariatric surgery outcomes through innovative behavioral strategies to increase physical activity.

Public Health Relevance

Bariatric surgery is currently the most effective treatment for severely obese individuals, although outcomes vary. Low physical activity is one behavioral factor that can undermine surgical success. Therefore, the goal of this research project is to increase physical activity and improve bariatric surgery outcomes in patients with low physical activity through innovatively targeting physical activity or sedentary behaviors.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01DK083438-04
Application #
8241116
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
2009-03-05
Project End
2014-02-28
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
4
Fiscal Year
2012
Total Cost
$139,487
Indirect Cost
$10,332
Name
Miriam Hospital
Department
Type
DUNS #
063902704
City
Providence
State
RI
Country
United States
Zip Code
02906
Bond, Dale S; Vithiananthan, Sivamainthan; Thomas, J Graham et al. (2015) Bari-Active: a randomized controlled trial of a preoperative intervention to increase physical activity in bariatric surgery patients. Surg Obes Relat Dis 11:169-77
Speck, Rebecca M; Bond, Dale S; Sarwer, David B et al. (2014) A systematic review of musculoskeletal pain among bariatric surgery patients: implications for physical activity and exercise. Surg Obes Relat Dis 10:161-70
Peterlin, B Lee; Rosso, Andrea L; Williams, Michelle A et al. (2013) Episodic migraine and obesity and the influence of age, race, and sex. Neurology 81:1314-21
Wing, Rena R; Bond, Dale S; Gendrano 3rd, Isaias Noel et al. (2013) Response to Comment on: Wing et al. Effect of intensive lifestyle intervention on sexual dysfunction in women with type 2 diabetes: results from an ancillary Look AHEAD Study. Diabetes care 2013;36:2937-2944. Diabetes Care 36:e191
Bond, Dale S; Thomas, J Graham; Unick, Jessica L et al. (2013) Self-reported and objectively measured sedentary behavior in bariatric surgery candidates. Surg Obes Relat Dis 9:123-8
Leahey, Tricia M; Bond, Dale S; Raynor, Hollie et al. (2012) Effects of bariatric surgery on food cravings: do food cravings and the consumption of craved foods "normalize" after surgery? Surg Obes Relat Dis 8:84-91
Bond, Dale S (2012) Comment on: Walking capacity of bariatric surgery candidates. Surg Obes Relat Dis 8:59-61
Joseph, R J; Alonso-Alonso, M; Bond, D S et al. (2011) The neurocognitive connection between physical activity and eating behaviour. Obes Rev 12:800-12
Bond, Dale S; Wing, Rena R; Vithiananthan, Sivamainthan et al. (2011) Significant resolution of female sexual dysfunction after bariatric surgery. Surg Obes Relat Dis 7:1-7
Bond, D S; Vithiananthan, S; Nash, J M et al. (2011) Improvement of migraine headaches in severely obese patients after bariatric surgery. Neurology 76:1135-8

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