The primary objective of this Mentored Research Scientist Development Award application is to provide mentored training and experience to enable the candidate to transition to an independent career in medical rehabilitation research. The candidate has clinical experience in Occupational Therapy and doctoral and postdoctoral training in the field of motor control and learning. The long-term goal is to become an expert in Movement Neuroscience and Neuroepidemiology. The short term goals during the four-year award include specific training in 1) interval timing control, 2) kinetic analysis of precision grip, 3) biostatistics, particularly regression and analysis of longitudinal data, and 4) Neuroepidemiology and clinical trials related to observational studies, outcome measures, and design of clinical trials. The mentored research program has two aims 1) to investigate mechanisms underlying motor impairments in Huntington's disease (HD) by testing whether they arise due to deficits in interval timing control or deficits in processing sensory feedback. Presymptomatic, symptomatic HD subjects and healthy controls will be tested with a cross-sectional design on two tasks (time reproduction and discrimination &precision grip) that allow for systematic manipulation of temporal and sensory information;2) to determine the longitudinal rate of change and predictive validity of quantitative motor measures to serve as reliable outcomes for future rehabilitation trials. Presymptomatic, symptomatic HD subjects and controls will be tested on gait, precision grip and functional tasks once a year for three years. Results of this research will help clarify neural mechanisms underlying motor impairments in HD, establish reliable and sensitive markers and provide data for planning a pilot clinical rehabilitation trial. The proposed training and mentored research will facilitate the candidate's transition to an independent researcher in medical rehabilitation. The proposed project is in line with the Institute's priority to understand system responses to physical impairments, functional changes, and developing precise methods of measuring impairments and functional limitations.

Public Health Relevance

The proposed project will help identify fundamental mechanisms that may be amenable to rehabilitation, and provide sensitive and predictive outcome measures for future clinical trials. This methodological approach may be beneficial for other neurodegenerative diseases such as Parkinson's disease and spinocerebellar ataxias.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01HD060912-04
Application #
8494646
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Michel, Mary E
Project Start
2010-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$128,279
Indirect Cost
$9,502
Name
Columbia University (N.Y.)
Department
Physical Medicine & Rehab
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Rao, Ashwini K; Gilman, Arthur; Louis, Elan D (2014) Balance confidence and falls in nondemented essential tremor patients: the role of cognition. Arch Phys Med Rehabil 95:1832-7
Abbruzzese, Laurel D; Rao, Ashwini K; Bellows, Rachel et al. (2014) Effects of manual task complexity on gait parameters in school-aged children and adults. Gait Posture 40:658-63
Rao, Ashwini K; Marder, Karen S; Uddin, Jasim et al. (2014) Variability in interval production is due to timing-dependent deficits in Huntington's disease. Mov Disord 29:1516-22
Montes, Jacqueline; Dunaway, Sally; Garber, Carol Ewing et al. (2014) Leg muscle function and fatigue during walking in spinal muscular atrophy type 3. Muscle Nerve 50:34-9
Rao, Ashwini K; Chou, Aileen; Bursley, Brett et al. (2014) Systematic review of the effects of exercise on activities of daily living in people with Alzheimer's disease. Am J Occup Ther 68:50-6
Rao, Ashwini K; Uddin, Jasim; Gillman, Arthur et al. (2013) Cognitive motor interference during dual-task gait in essential tremor. Gait Posture 38:403-9
Montes, Jacqueline; McIsaac, Tara L; Dunaway, Sally et al. (2013) Falls and spinal muscular atrophy: exploring cause and prevention. Muscle Nerve 47:118-23
Louis, Elan D; Rao, Ashwini K; Gerbin, Marina (2012) Functional correlates of gait and balance difficulty in essential tremor: balance confidence, near misses and falls. Gait Posture 35:43-7
Rao, Ashwini K; Gordon, Andrew M; Marder, Karen S (2011) Coordination of fingertip forces during precision grip in premanifest Huntington's disease. Mov Disord 26:862-9
Rao, Ashwini K; Gillman, Arthur; Louis, Elan D (2011) Quantitative gait analysis in essential tremor reveals impairments that are maintained into advanced age. Gait Posture 34:65-70