The candidate's long-term goal is to pursue an academic career as a cognitive neuroscientist with a focus on executive control of cognitive processes such as attention, working memory, and decision making, using EEC, MEG, and fMRI as the primary investigative tools. The purpose of the training is to gain expertise in these methods and in particular their integration. The candidate will be instructed by experts in the field on the use of these methods and on issues related to visual perception and selective attention. Facilities for the acquisition and analysis of EEC , MEG, and fMRI data will be available. The goal of the research plan is to develop a new retinotopy-constrained source estimation method and use this new method to estimate the time courses of activation in multiple visual areas. Retinotopic maps measured with fMRI and surface tesselations constructed from high resolution MRI images will be used to create realistic, highly detailed models of the cortical generators of visual evoked responses measured with MEG and EEG. Source estimates will be constrained by MEG and EEG responses to stimuli at multiple iso-eccentricity visual field locations. As the stimulus location changes, the equivalent current dipole in a given visual area moves across the cortical surface in a way predicted by fMRI retinotopy data. As a validation of this method, stimulus contrast and spatial frequency will be varied. The modulation of source estimates will be compared to the modulation of event-related fMRI responses to the same stimuli. Finally, this method will be used to measure the temporal profile of modulation in individual cortical areas by selective spatial attention. Furthermore, activity in early visual areas will be compared to activity in the attentional control network comprising posterior parietal cortex, frontal eye fields, and dorsolateral prefrontal cortex. It is anticipated that methods developed will be of considerable use in the future study of visual perception and attentional control in normal subjects and may provide a valuable, non-invasive method for the diagnosis and translational study of disorders of attentional control such as attention-deficit disorder, autism spectrum disorders, and schizophrenia. This career development award will provide necessary training in multi-modal brain imaging methods as well as an opportunity to develop and test ideas, creating strategies and foundations for future study.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01MH079146-04
Application #
8117655
Study Section
Cognition and Perception Study Section (CP)
Program Officer
Vogel, Michael W
Project Start
2008-08-21
Project End
2012-12-31
Budget Start
2011-08-01
Budget End
2012-12-31
Support Year
4
Fiscal Year
2011
Total Cost
$136,552
Indirect Cost
Name
University of California San Diego
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Marinkovic, Ksenija; Rosen, Burke Q; Cox, Brendan et al. (2014) Spatio-temporal processing of words and nonwords: hemispheric laterality and acute alcohol intoxication. Brain Res 1558:18-32
Hagler Jr, Donald J (2014) Visual field asymmetries in visual evoked responses. J Vis 14:13
Hagler Jr, Donald J (2014) Optimization of retinotopy constrained source estimation constrained by prior. Hum Brain Mapp 35:1815-33
Hagler Jr, Donald J; Dale, Anders M (2013) Improved method for retinotopy constrained source estimation of visual-evoked responses. Hum Brain Mapp 34:665-83
Travis, Katherine E; Leonard, Matthew K; Brown, Timothy T et al. (2011) Spatiotemporal neural dynamics of word understanding in 12- to 18-month-old-infants. Cereb Cortex 21:1832-9
Seibert, Tyler M; Hagler Jr, Donald J; Brewer, James B (2011) Early parietal response in episodic retrieval revealed with MEG. Hum Brain Mapp 32:171-81
Seibert, Tyler M; Gimbel, Sarah I; Hagler Jr, Donald J et al. (2011) Parietal activity in episodic retrieval measured by fMRI and MEG. Neuroimage 55:788-93
Chang, Yu-Ling; Bondi, Mark W; Fennema-Notestine, Christine et al. (2010) Brain substrates of learning and retention in mild cognitive impairment diagnosis and progression to Alzheimer's disease. Neuropsychologia 48:1237-47
Hagler Jr, Donald J; Halgren, Eric; Martinez, Antigona et al. (2009) Source estimates for MEG/EEG visual evoked responses constrained by multiple, retinotopically-mapped stimulus locations. Hum Brain Mapp 30:1290-309
McDonald, C R; McEvoy, L K; Gharapetian, L et al. (2009) Regional rates of neocortical atrophy from normal aging to early Alzheimer disease. Neurology 73:457-65