This Mentored Research Scientist Development Award application describes training and research plans designed to qualify the candidate for a career as an independent mental health researcher with expertise in the implications of co-morbid psychopathology for the etiology, classification and treatment of eating disorders. Unrecognized systematic heterogeneity within the population of individuals with eating disorders may produce inconsistent findings across studies (e.g., if heterogeneous subgroups are entered in different proportions in different studies) and obscure clinically relevant information about etiology, prognosis and treatment response. In this application, the research plan focuses on understanding how heterogeneity in patterns of co-morbid mood and anxiety psychopathology is related to treatment response in patients with anorexia nervosa (AN). To this end, the underlying structure of mood and anxiety disorder co-morbidity will be examined in 150 AN patients using dimensional measures of psychiatric symptomatology and temperament. Participants will be assessed 1-2 weeks after admission for acute (i.e., inpatient or day hospital) treatment at a large, well established specialty care program and then followed closely for 12 months after discharge to determine whether co-morbidity subtypes have utility for identifying predictors of treatment response in AN. Guided by an interdisciplinary team of mentors, advanced training in 1) clinical and etiologic factors relevant to research with AN patients;2) dimensional approaches to the study of psychopathology;and 3) data analytic techniques for identifying clinical subgroups and modeling longitudinal outcomes will facilitate the candidate's goal of establishing an independent research career focusing on the psychopathology and treatment of AN. Information about differences among AN patients with respect to mood and anxiety disorder symptoms and personality traits will promote treatment development initiatives by identifying potential targets for novel interventions. Further, a better understanding of factors related to negative outcome during the period immediately following discharge from acute treatment may lead to the development of more effective treatments and relapse prevention programs. Finally, understanding robust differences in symptom patterns among patients with AN may provide clues that will promote research on the complex causes of this pernicious disorder.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Scientist Development Award - Research & Training (K01)
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Special Emphasis Panel (ZRG1-BBBP-M (02))
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Chavez, Mark
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University of Pittsburgh
Schools of Medicine
United States
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Wildes, Jennifer E; Forbush, Kelsie T; Hagan, Kelsey E et al. (2017) Characterizing severe and enduring anorexia nervosa: An empirical approach. Int J Eat Disord 50:389-397
Bodell, Lindsay P; Racine, Sarah E; Wildes, Jennifer E (2016) Examining weight suppression as a predictor of eating disorder symptom trajectories in anorexia nervosa. Int J Eat Disord 49:753-63
Racine, Sarah E; Wildes, Jennifer E (2015) Emotion dysregulation and anorexia nervosa: an exploration of the role of childhood abuse. Int J Eat Disord 48:55-8
Racine, Sarah E; Wildes, Jennifer E (2015) Dynamic longitudinal relations between emotion regulation difficulties and anorexia nervosa symptoms over the year following intensive treatment. J Consult Clin Psychol 83:785-95
Wildes, Jennifer E; Marcus, Marsha D (2013) Alternative methods of classifying eating disorders: models incorporating comorbid psychopathology and associated features. Clin Psychol Rev 33:383-94
Wildes, Jennifer E; Forbush, Kelsie T; Markon, Kristian E (2013) Characteristics and stability of empirically derived anorexia nervosa subtypes: towards the identification of homogeneous low-weight eating disorder phenotypes. J Abnorm Psychol 122:1031-41
Wildes, Jennifer E; Marcus, Marsha D (2013) Incorporating dimensions into the classification of eating disorders: three models and their implications for research and clinical practice. Int J Eat Disord 46:396-403
Racine, Sarah E; Wildes, Jennifer E (2013) Emotion dysregulation and symptoms of anorexia nervosa: the unique roles of lack of emotional awareness and impulse control difficulties when upset. Int J Eat Disord 46:713-20
Wildes, Jennifer E; Marcus, Marsha D (2012) Weight suppression as a predictor of weight gain and response to intensive behavioral treatment in patients with anorexia nervosa. Behav Res Ther 50:266-74
Wildes, Jennifer E; Marcus, Marsha D; Bright, Ashley C et al. (2012) Emotion and eating disorder symptoms in patients with anorexia nervosa: an experimental study. Int J Eat Disord 45:876-82

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