This ADAMHA Research Scientist Development Award is sought to support the applicant's development as a scientist committed to research designed to improve alcoholism treatment. The research plan includes two studies that derive from the candidate's work with naltrexone, an opioid antagonist, in the treatment of alcohol dependence. In the first study, a laboratory alcohol self-administration paradigm will be used to examine the mechanism of action for the efficacy of naltrexone. The second study examines optimal strategies for using naltrexone clinically, including the level of psychotherapy required in conjunction with naltrexone treatment and the optimal duration of treatment. Patient characteristics that may interact differentially with naltrexone will also be examined in these studies.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Scientist Development Award - Research (K02)
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Clinical and Treatment Subcommittee (ALCP)
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Yale University
Schools of Medicine
New Haven
United States
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O'Malley, Stephanie S; Krishnan-Sarin, Suchitra; McKee, Sherry A et al. (2009) Dose-dependent reduction of hazardous alcohol use in a placebo-controlled trial of naltrexone for smoking cessation. Int J Neuropsychopharmacol 12:589-97
McKee, Sherry A; Carroll, Kathleen M; Sinha, Rajita et al. (2007) Enhancing brief cognitive-behavioral therapy with motivational enhancement techniques in cocaine users. Drug Alcohol Depend 91:97-101
O'Malley, Stephanie S; Cooney, Judith L; Krishnan-Sarin, Suchitra et al. (2006) A controlled trial of naltrexone augmentation of nicotine replacement therapy for smoking cessation. Arch Intern Med 166:667-74
Petrakis, Ismene L; O'Malley, Stephanie; Rounsaville, Bruce et al. (2004) Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia. Psychopharmacology (Berl) 172:291-7
Potenza, Marc N; Steinberg, Marvin A; McLaughlin, Susan D et al. (2004) Characteristics of tobacco-smoking problem gamblers calling a gambling helpline. Am J Addict 13:471-93
Krishnan-Sarin, Suchitra; Meandzija, Boris; O'Malley, Stephanie (2003) Naltrexone and nicotine patch smoking cessation: a preliminary study. Nicotine Tob Res 5:851-7
Froehlich, Janice; O'Malley, Stephanie; Hyytia, Petri et al. (2003) Preclinical and clinical studies on naltrexone: what have they taught each other? Alcohol Clin Exp Res 27:533-9
O'Malley, Stephanie S; Rounsaville, Bruce J; Farren, Conor et al. (2003) Initial and maintenance naltrexone treatment for alcohol dependence using primary care vs specialty care: a nested sequence of 3 randomized trials. Arch Intern Med 163:1695-704
O'Malley, Stephanie S; Froehlich, Janice C (2003) Advances in the use of naltrexone: an integration of preclinical and clinical findings. Recent Dev Alcohol 16:217-45
Baker, Timothy B; Hatsukami, Dorothy K; Lerman, Caryn et al. (2003) Transdisciplinary science applied to the evaluation of treatments for tobacco use. Nicotine Tob Res 5 Suppl 1:S89-99

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