The goal of this independent scientist award (K02) application is to provide the Candidate with protected time to conduct research on initiation and progression of alcohol use. A host of powerful analytic methods and readily available specialized software have recently been developed that allow for empirical testing of hypotheses of change, but recent emphasis on statistical advances may divert attention from theory. Making inferences about age-related changes from empirical data requires attention to issues of design, measurement, and analysis. To the degree that the issues affect the correspondence between statistical models and theories of development, our ability to validly test developmental theory is threatened. This proposal seeks to illustrate and address key challenges that arise when translating theory to empirical findings by applying newly emerging methods for modeling development. These include developmental (dis)continuity, heterotypic continuity, approaches to modeling covariates, origin and metric of the time scale, and cohort sequential design. Developmental methods will be applied to four prospective datasets on underage alcohol use: three secondary datasets that span adolescence through young adulthood and the Candidate's NIAAA-funded study, """"""""Initiation and Progression through Early Drinking Milestones in Underage Drinkers"""""""" (R01 AA016838), a study exploring characteristics of the early drinking career in a multi-cohort sample of 1,023 Rhode Island middle schoolers, for which data collection is ongoing and data processing is underway. The secondary datasets, the National Longitudinal Survey of Youth (NLSY97), the Michigan Longitudinal Study (MLS), and the Minnesota Twin Family Study (MTFS), offer advantages with regard to sampling, follow-up interval and duration, operationalization of alcohol involvement, and type of risk factors assessed. Together, these four datasets will address important substantive research questions about the predictive utility of drinking precursors and risk factors at the level of the individual social context, and broader context, as well as outcomes of risky alcohol use. In addition, the extent to which initiation and progression vary by age, across stage of alcohol involvement, and over important life transitions will be examined. Career development activities take the form of research collaborations with nationally recognized consultants in the fields of quantitative psychology and developmental psychopathology that regularly develop, adapt, and employ methods to address questions of development using prospective data. These collaborations will result in joint manuscripts and will provide support for extensive, iterative interactions. Formal training activities include workshop attendance, didactic readings, and dissemination to the field in the form of review papers, symposia, and topical meetings. By the end of the award period, the Candidate will have the skills to bridge state-of-the-art emerging analytic techniques with developmental theory to substantially advance our knowledge of the etiology of alcohol initiation and progression of use and will be a leading expert in the application of models of change.

Public Health Relevance

Early use of alcohol is associated with increased risk of a number of subsequent adverse outcomes, including heavy or problem drinking, likelihood of developing an alcohol use disorder, other substance involvement, and behavioral problems. It is only by understanding the early course of alcohol use that we can implement successful prevention strategies to reduce underage drinking and ultimately improve the mental and physical health of our population.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Scientist Development Award - Research (K02)
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Health Services Research Review Subcommittee (AA)
Program Officer
Zha, Wenxing
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Brown University
Public Health & Prev Medicine
Schools of Public Health
United States
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Merrill, Jennifer E; Lopez-Vergara, Hector I; Barnett, Nancy P et al. (2016) Hypothetical Evaluations of Positive and Negative Alcohol Consequences in Adolescents Across Various Levels of Drinking Experience. Psychol Addict Behav :
Littlefield, Andrew K; Stevens, Angela K; Ellingson, Jarrod M et al. (2016) Changes in negative urgency, positive urgency, and sensation seeking across adolescence. Pers Individ Dif 90:332-337
Sartor, Carolyn E; Jackson, Kristina M; McCutcheon, Vivia V et al. (2016) Progression from First Drink, First Intoxication, and Regular Drinking to Alcohol Use Disorder: A Comparison of African American and European American Youth. Alcohol Clin Exp Res 40:1515-23
Lopez-Vergara, Hector I; Spillane, Nichea S; Merrill, Jennifer E et al. (2016) Developmental Trends in Alcohol Use Initiation and Escalation From Early to Middle Adolescence: Prediction by Urgency and Trait Affect. Psychol Addict Behav :
Jackson, Kristina M; Rogers, Michelle L; Sartor, Carolyn E (2016) Parental divorce and initiation of alcohol use in early adolescence. Psychol Addict Behav 30:450-61
Merrill, Jennifer E; Martin, Scott; Abar, Caitlin C et al. (2016) Trajectories and correlates of reasons for abstaining or limiting drinking during adolescence. Addict Behav 52:1-7
Jackson, Kristina M; Merrill, Jennifer E; Barnett, Nancy P et al. (2016) Contextual influences on early drinking: Characteristics of drinking and nondrinking days. Psychol Addict Behav 30:566-577
Wood, Phillip K; Steinley, Douglas; Jackson, Kristina M (2015) Right-sizing statistical models for longitudinal data. Psychol Methods 20:470-88
Marceau, Kristine; Abar, Caitlin C; Jackson, Kristina M (2015) Parental Knowledge is a Contextual Amplifier of Associations of Pubertal Maturation and Substance Use. J Youth Adolesc 44:1720-34
Borsari, Brian; Apodaca, Timothy R; Jackson, Kristina M et al. (2015) In-session processes of brief motivational interventions in two trials with mandated college students. J Consult Clin Psychol 83:56-67

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